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Background <p>Particulate matter less than 2.5 microns in aerodynamic diameter (PM<sub>2.5</sub>) is a significant air pollutant known to adversely affect respiratory health and increase the incidence of chronic obstructive pulmonary disease (COPD). Furthermore, climate change exacerbates these impacts, as extreme temperatures and relative humidity (RH) levels can intensify the effects of PM<sub>2.5</sub>. This study aims to examine the joint effects of PM<sub>2.5</sub>, temperature, and RH on the risk of COPD.</p> Methods <p>A case–control study was conducted among 1,828 participants from 2017 to 2022 (995 COPD patients and 833 controls). The radial basis function interpolation was utilized to estimate participants' individual mean and differences in PM<sub>2.5</sub>, temperature, and RH in 1-day, 7-day, and 1-month periods. Logistic regression models examined the associations of environmental exposures with the risk of COPD adjusting for confounders. Joint effects of PM<sub>2.5</sub> by quartiles of temperature and RH were also examined.</p> Results <p>We observed that a 1&#xa0;µg/m<sup>3</sup> increase in PM<sub>2.5</sub> 7-day and 1-month mean was associated with a 1.05-fold and 1.06-fold increase in OR of COPD (<i>p</i> &lt; <i>0.05</i>). For temperature and RH, we observed U-shaped effects on OR for COPD with optimal temperatures identified as 21.2&#xa0;°C, 23.8&#xa0;°C, and 23.8&#xa0;°C for 1-day, 7-day, and 1-month mean temperature, respectively, and optimal RH levels identified as 73.8%, 76.7%, and 75.4% for 1-day, 7-day, and 1-month mean RH, respectively (<i>p</i> &lt; <i>0.05</i>). The joint effect models show that high temperatures (&gt; 23.5&#xa0;°C) and both extremely low (69.3%) and high (80.9%) RH levels generally exacerbate the effects of PM<sub>2.5</sub> on OR for COPD, especially over longer exposure durations.</p> Conclusion <p>The joint effects of PM<sub>2.5</sub>, temperature, and RH on the risk of COPD underscore the importance of air pollution control and comprehensive research to mitigate COPD risk in the context of climate change.</p>

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Joint effects of temperature and humidity with PM2.5 on COPD

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月3日

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  • Huan Minh Tran,
  • Feng-Jen Tsai,
  • Yuan-Hung Wang,
  • Kang-Yun Lee,
  • Jer-Hwa Chang,
  • Chi-Li Chung,
  • Chien-Hua Tseng,
  • Chien-Ling Su,
  • Yuan-Chien Lin,
  • Tzu-Tao Chen,
  • Kuan-Yuan Chen,
  • Shu-Chuan Ho,
  • Feng-Ming Yang,
  • Sheng-Ming Wu,
  • Kian Fan Chung,
  • Kin-Fai Ho,
  • Kai-Jen Chuang,
  • Hsiao-Chi Chuang

摘要

Background

Particulate matter less than 2.5 microns in aerodynamic diameter (PM2.5) is a significant air pollutant known to adversely affect respiratory health and increase the incidence of chronic obstructive pulmonary disease (COPD). Furthermore, climate change exacerbates these impacts, as extreme temperatures and relative humidity (RH) levels can intensify the effects of PM2.5. This study aims to examine the joint effects of PM2.5, temperature, and RH on the risk of COPD.

Methods

A case–control study was conducted among 1,828 participants from 2017 to 2022 (995 COPD patients and 833 controls). The radial basis function interpolation was utilized to estimate participants' individual mean and differences in PM2.5, temperature, and RH in 1-day, 7-day, and 1-month periods. Logistic regression models examined the associations of environmental exposures with the risk of COPD adjusting for confounders. Joint effects of PM2.5 by quartiles of temperature and RH were also examined.

Results

We observed that a 1 µg/m3 increase in PM2.5 7-day and 1-month mean was associated with a 1.05-fold and 1.06-fold increase in OR of COPD (p < 0.05). For temperature and RH, we observed U-shaped effects on OR for COPD with optimal temperatures identified as 21.2 °C, 23.8 °C, and 23.8 °C for 1-day, 7-day, and 1-month mean temperature, respectively, and optimal RH levels identified as 73.8%, 76.7%, and 75.4% for 1-day, 7-day, and 1-month mean RH, respectively (p < 0.05). The joint effect models show that high temperatures (> 23.5 °C) and both extremely low (69.3%) and high (80.9%) RH levels generally exacerbate the effects of PM2.5 on OR for COPD, especially over longer exposure durations.

Conclusion

The joint effects of PM2.5, temperature, and RH on the risk of COPD underscore the importance of air pollution control and comprehensive research to mitigate COPD risk in the context of climate change.