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Background <p>Adolescent negative life events are important risk factors for affective disorders. However, it remains unclear whether visual comprehension mediates the relationship between negative life events and affective disorders. This study proposed that visual comprehension mediates the relationship between negative life events and affective disorders and that higher-level comprehensive control moderates this model. It also compared the dominant positions of the visual and auditory response control.</p> Methods <p>Data were collected from 101 adolescent and young adult participants with first-episode depressive disorders attending a health centre outpatient department; of these, 84 met the inclusion criteria and were included in the final sample. Negative life event levels was assessed using the Adolescent Self-Rating Life Events Checklist (ASLEC) and affective disorders, Self-Rating Depression Scale, Self-Rating Anxiety Scale, and Symptom Checklist-90. Cognitive function was quantified using an integrated continuous visual and auditory performance test. The moderated mediation model comprised ASLEC as the independent variable; affective disorder, dependent; visual comprehension quotient (VCQ), mediator; and full-scale response control quotient (FSRCQ) and auditory response control quotients (ARCQ), moderators.</p> Results <p>VCQ mediated the relationship between ASLEC and affective disorders. FSRCQ moderated the overall model and the association between ASLEC and VCQ. ARCQ also moderated this model. Negative life events significantly positively correlated with affective disorders, with higher levels predicting higher severity. Moreover, visual comprehension facilitated this relationship, with an increase in negative life events significantly weakening visual comprehension, thereby exacerbating affective disorders. Individuals with higher comprehensive and auditory response controls showed stronger inhibitory effect of negative life events on visual comprehension.</p> Conclusions <p>This study provides preliminary empirical evidence of the relationship between negative life events, cognitive function, and affective disorders. Cognitive function mediates negative life events’ impact on affective disorders in adolescents and young adults. In particular, auditory response control moderates the association between negative life events and visual comprehension.</p>

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The impact of negative life events on adolescents and young adults affective disorders: a moderated mediation analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月29日

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  • Youshan Ma,
  • Fuling Wan,
  • Jinglong Wu,
  • Zhilin Zhang,
  • Lichang Yao,
  • Ting Jiang,
  • Xiujun Li,
  • Qingwen Xiao,
  • Kaiyuan Chen,
  • Qi Dai,
  • Jinling Zhang

摘要

Background

Adolescent negative life events are important risk factors for affective disorders. However, it remains unclear whether visual comprehension mediates the relationship between negative life events and affective disorders. This study proposed that visual comprehension mediates the relationship between negative life events and affective disorders and that higher-level comprehensive control moderates this model. It also compared the dominant positions of the visual and auditory response control.

Methods

Data were collected from 101 adolescent and young adult participants with first-episode depressive disorders attending a health centre outpatient department; of these, 84 met the inclusion criteria and were included in the final sample. Negative life event levels was assessed using the Adolescent Self-Rating Life Events Checklist (ASLEC) and affective disorders, Self-Rating Depression Scale, Self-Rating Anxiety Scale, and Symptom Checklist-90. Cognitive function was quantified using an integrated continuous visual and auditory performance test. The moderated mediation model comprised ASLEC as the independent variable; affective disorder, dependent; visual comprehension quotient (VCQ), mediator; and full-scale response control quotient (FSRCQ) and auditory response control quotients (ARCQ), moderators.

Results

VCQ mediated the relationship between ASLEC and affective disorders. FSRCQ moderated the overall model and the association between ASLEC and VCQ. ARCQ also moderated this model. Negative life events significantly positively correlated with affective disorders, with higher levels predicting higher severity. Moreover, visual comprehension facilitated this relationship, with an increase in negative life events significantly weakening visual comprehension, thereby exacerbating affective disorders. Individuals with higher comprehensive and auditory response controls showed stronger inhibitory effect of negative life events on visual comprehension.

Conclusions

This study provides preliminary empirical evidence of the relationship between negative life events, cognitive function, and affective disorders. Cognitive function mediates negative life events’ impact on affective disorders in adolescents and young adults. In particular, auditory response control moderates the association between negative life events and visual comprehension.