Background <p>We investigated alterations in impulsive choice and impulsive action among individuals with methamphetamine use disorder (MUD) compared to a control group after exposure to cues associated with methamphetamine (METH).</p> Methods <p>Thirty-four participants with MUD and 31 healthy participants were instructed to experience a METH-related virtual reality (VR) social environment and to perform the go/no-go task as well as the balloon analog risk task (BART) before (the baseline condition) and after (the cue-induced condition) watching a VR video.</p> Results <p>There were no significant differences between groups for go/no-go task both in the baseline condition and cue-induced condition. The METH group exhibited more adjusted pumps in the cue-induced condition than in the baseline condition. The λ (loss aversion) of the METH group was significantly lower in the cue-induced condition than in the baseline condition. In the correlation analysis of behavioral data and the exponential-weight mean-variance (EWMV) parameters, λ was the only parameter related to adjusted pumps both in the baseline condition and the cue-induced condition, reflected by a strong negative correlation.</p> Conclusions <p>These findings suggest that METH related cues may impact impulsive choice, but not impulsive action, by decreasing loss aversion.</p>

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Methamphetamine related cues impact impulsive choice by decreasing loss aversion

  • Yu Han,
  • Rui-si Xu,
  • Xiang-yi Zhou,
  • Xiao-huang-hao Yang,
  • Rui-yi Chen,
  • Qian-qian Lin,
  • Zhi-hua Shen,
  • Yong-guang Wang

摘要

Background

We investigated alterations in impulsive choice and impulsive action among individuals with methamphetamine use disorder (MUD) compared to a control group after exposure to cues associated with methamphetamine (METH).

Methods

Thirty-four participants with MUD and 31 healthy participants were instructed to experience a METH-related virtual reality (VR) social environment and to perform the go/no-go task as well as the balloon analog risk task (BART) before (the baseline condition) and after (the cue-induced condition) watching a VR video.

Results

There were no significant differences between groups for go/no-go task both in the baseline condition and cue-induced condition. The METH group exhibited more adjusted pumps in the cue-induced condition than in the baseline condition. The λ (loss aversion) of the METH group was significantly lower in the cue-induced condition than in the baseline condition. In the correlation analysis of behavioral data and the exponential-weight mean-variance (EWMV) parameters, λ was the only parameter related to adjusted pumps both in the baseline condition and the cue-induced condition, reflected by a strong negative correlation.

Conclusions

These findings suggest that METH related cues may impact impulsive choice, but not impulsive action, by decreasing loss aversion.