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Objective <p>To explore the diagnostic value of Matrix Metallopeptidase 7 (MMP-7) alongside serological markers in identifying liver fibrosis in children with biliary atresia (BA).</p> Methods <p>A retrospective study was conducted to analyze the general information, liver fibrosis stage, and laboratory results, including MMP-7, of children with BA who underwent Kasai portoenterostomy between 2022 and 2024 at two Chinese hospitals. The aspartate aminotransferase to platelet ratio index (APRI), Fibrosis 4 Score (FIB-4), and infant biliary atresia liver fibrosis (iBALF) score were calculated according to the formula.</p> Results <p>Significant differences in APRI, FIB-4, iBALF score, and MMP-7 were observed across fibrosis stages.When differentiating different stages of liver fibrosis, FIB-4 demonstrated the highest AUC values (0.807 and 0.815) for identifying liver fibrosis stages ≥ F2 and ≥ F3, and the optimal cut-off values were 0.073 and 0.105. For evaluating stage F4, MMP-7 showed the highest AUC value of 0.793, with an optimal cut-off of 68.94. Combining MMP-7 with other markers improved diagnostic accuracy, particularly MMP-7 + iBALF score for cirrhosis (F4: AUC = 0.844).</p> Conclusion <p>Serological markers like FIB-4, iBALF score, and MMP-7 can reflect various levels of liver fibrosis. Among these, the combination of MMP-7 and iBALF score is the most effective in differentiating liver cirrhosis.</p>

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The value of MMP-7 combined with serological markers in diagnosing liver fibrosis in children with biliary atresia

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月22日

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  • Bingliang Li,
  • Yingyu Jia,
  • Yanfu Wang,
  • Zhibo Zhang,
  • Hongxia Ren

摘要

Objective

To explore the diagnostic value of Matrix Metallopeptidase 7 (MMP-7) alongside serological markers in identifying liver fibrosis in children with biliary atresia (BA).

Methods

A retrospective study was conducted to analyze the general information, liver fibrosis stage, and laboratory results, including MMP-7, of children with BA who underwent Kasai portoenterostomy between 2022 and 2024 at two Chinese hospitals. The aspartate aminotransferase to platelet ratio index (APRI), Fibrosis 4 Score (FIB-4), and infant biliary atresia liver fibrosis (iBALF) score were calculated according to the formula.

Results

Significant differences in APRI, FIB-4, iBALF score, and MMP-7 were observed across fibrosis stages.When differentiating different stages of liver fibrosis, FIB-4 demonstrated the highest AUC values (0.807 and 0.815) for identifying liver fibrosis stages ≥ F2 and ≥ F3, and the optimal cut-off values were 0.073 and 0.105. For evaluating stage F4, MMP-7 showed the highest AUC value of 0.793, with an optimal cut-off of 68.94. Combining MMP-7 with other markers improved diagnostic accuracy, particularly MMP-7 + iBALF score for cirrhosis (F4: AUC = 0.844).

Conclusion

Serological markers like FIB-4, iBALF score, and MMP-7 can reflect various levels of liver fibrosis. Among these, the combination of MMP-7 and iBALF score is the most effective in differentiating liver cirrhosis.