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Background <p>Immunomodulation and respiratory health have a critical role in the offspring well-being. Maternal status of vitamin D during pregnancy seems to have immunomodulatory and respiratory protective effects in children. However, evidence regarding respiratory and allergy-related outcomes remains conflicting. Therefore, this study aimed to synthesize the available data in this regard to provide a firm direction.</p> Methods <p>Comprehensive searches were made in the databases of PubMed, Scopus, the Web of Science, and the Cochrane Library until August 2025. We included randomized controlled trials (RCTs) to evaluate the effects of maternal intake of vitamin D during pregnancy on outcomes in children with respiratory and allergy conditions. Also, the quality of evidence was evaluated using GRADE method and the Cochrane risk-of-bias tool was used to evaluate study quality.</p> Results <p>Seven RCTs were included. Prenatal supplementation of vitamin D did not affect respiratory outcomes in the children who followed: RTI (RR: 1.04; 95% CI: 0.99, 1.09; <i>P</i> = 0.122, <i>I</i><sup>2</sup> = 0.0%), asthma (RR: 0.94; 95% CI: 0.67, 1.31; <i>P</i> = 0.701, <i>I</i><sup>2</sup> = 64.9%), and wheezing (RR: 0.82; 95% CI: 0.62, 1.09; <i>P</i> = 0.176, <i>I</i><sup>2</sup> = 0.0%). Similarly, vitamin D supplementation in pregnant women was associated with non-significant effects on eczema (RR: 0.95; 95% CI: 0.83, 1.10; <i>P</i> = 0.524, <i>I</i><sup>2</sup> = 0.0%), allergic condition (RR: 0.95; 95% CI: 0.85, 1.06; <i>P</i> = 0.324, <i>I</i><sup>2</sup> = 0.0%), and immunoglobulin E (IgE) (RR: 0.94; 95% CI: 0.73, 1.21; <i>P</i> = 0.639, <i>I</i><sup>2</sup> = 52.6%) in children.</p> Conclusion <p>Overall, the vitamin D supplementation during pregnancy has no significant effect on respiratory and allergy-related outcomes in children.</p>

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Association between prenatal vitamin D supplementation and respiratory diseases in children: a systematic review and meta-analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月7日

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  • Jieru Shen,
  • Zhonghui Zhou,
  • Fao Feng,
  • Yu Zhang,
  • Sayu Bao,
  • Yangrong Feng

摘要

Background

Immunomodulation and respiratory health have a critical role in the offspring well-being. Maternal status of vitamin D during pregnancy seems to have immunomodulatory and respiratory protective effects in children. However, evidence regarding respiratory and allergy-related outcomes remains conflicting. Therefore, this study aimed to synthesize the available data in this regard to provide a firm direction.

Methods

Comprehensive searches were made in the databases of PubMed, Scopus, the Web of Science, and the Cochrane Library until August 2025. We included randomized controlled trials (RCTs) to evaluate the effects of maternal intake of vitamin D during pregnancy on outcomes in children with respiratory and allergy conditions. Also, the quality of evidence was evaluated using GRADE method and the Cochrane risk-of-bias tool was used to evaluate study quality.

Results

Seven RCTs were included. Prenatal supplementation of vitamin D did not affect respiratory outcomes in the children who followed: RTI (RR: 1.04; 95% CI: 0.99, 1.09; P = 0.122, I2 = 0.0%), asthma (RR: 0.94; 95% CI: 0.67, 1.31; P = 0.701, I2 = 64.9%), and wheezing (RR: 0.82; 95% CI: 0.62, 1.09; P = 0.176, I2 = 0.0%). Similarly, vitamin D supplementation in pregnant women was associated with non-significant effects on eczema (RR: 0.95; 95% CI: 0.83, 1.10; P = 0.524, I2 = 0.0%), allergic condition (RR: 0.95; 95% CI: 0.85, 1.06; P = 0.324, I2 = 0.0%), and immunoglobulin E (IgE) (RR: 0.94; 95% CI: 0.73, 1.21; P = 0.639, I2 = 52.6%) in children.

Conclusion

Overall, the vitamin D supplementation during pregnancy has no significant effect on respiratory and allergy-related outcomes in children.