Scholarlink

Background <p>This study aimed to examine the association between constipation and appendicitis in children using data from a nationwide birth cohort, the Japan Environment and Children's Study (JECS).</p> Methods <p>Data were obtained from 64,772 children and their mothers participating in JECS, which included over 100,000 pregnancies across 15 regional centres in Japan. Pediatric constipation was assessed at age three using the Rome III criteria, while appendicitis cases were identified between ages three to four. Logistic regression analyses, including univariable and multivariable models, were conducted to evaluate associations. Additional analyses were stratified by sex.</p> Results <p>Among the 64,772 children analyzed, 156 cases of appendicitis were identified between the ages of 3 and 4&#xa0;years. Logistic regression suggested a possible association between constipation and an increased risk of appendicitis (univariable odds ratio [OR]: 1.38, 95% confidence interval [CI]: 0.87–2.10; multivariable OR: 1.36, 95% CI: 0.86–2.06). Although the associations did not reach statistical significance, the point estimates consistently indicated a trend toward increased risk.</p> Conclusion <p>Although our analyses of children aged 3–4&#xa0;years did not yield statistically significant associations, the observed trends may suggest a potential link between constipation and appendicitis. These findings should be interpreted only as exploratory, and further studies in different age groups, including older children and adults, are warranted to confirm or refute this possible association.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The impact of pediatric constipation on appendicitis: a prospective birth cohort in the Japan Environment and Children’s Study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月26日

查看全文
  • Hiroyoshi Iwata,
  • Takeshi Yamaguchi,
  • Sachiko Itoh,
  • Yu Ait Bamai,
  • Atsuko Ikeda,
  • Keitaro Makino,
  • Mariko Itoh,
  • Maki Tojo,
  • Rieko Yamamoto,
  • Naomi Tamura,
  • Rahel Mesfin Ketema,
  • Yasuaki Saijo,
  • Yoshiya Ito,
  • Reiko Kishi,
  • Michihiro Kamijima,
  • Shin Yamazaki,
  • Maki Fukami,
  • Chiharu Ota,
  • Koichi Hashimoto,
  • Chisato Mori,
  • Shuichi Ito,
  • Ryoji Shinohara,
  • Hidekuni Inadera,
  • Takeo Nakayama,
  • Ryo Kawasaki,
  • Yasuhiro Takeshima,
  • Seiji Kageyama,
  • Narufumi Suganuma,
  • Shoichi Ohga,
  • Takahiko Katoh

摘要

Background

This study aimed to examine the association between constipation and appendicitis in children using data from a nationwide birth cohort, the Japan Environment and Children's Study (JECS).

Methods

Data were obtained from 64,772 children and their mothers participating in JECS, which included over 100,000 pregnancies across 15 regional centres in Japan. Pediatric constipation was assessed at age three using the Rome III criteria, while appendicitis cases were identified between ages three to four. Logistic regression analyses, including univariable and multivariable models, were conducted to evaluate associations. Additional analyses were stratified by sex.

Results

Among the 64,772 children analyzed, 156 cases of appendicitis were identified between the ages of 3 and 4 years. Logistic regression suggested a possible association between constipation and an increased risk of appendicitis (univariable odds ratio [OR]: 1.38, 95% confidence interval [CI]: 0.87–2.10; multivariable OR: 1.36, 95% CI: 0.86–2.06). Although the associations did not reach statistical significance, the point estimates consistently indicated a trend toward increased risk.

Conclusion

Although our analyses of children aged 3–4 years did not yield statistically significant associations, the observed trends may suggest a potential link between constipation and appendicitis. These findings should be interpreted only as exploratory, and further studies in different age groups, including older children and adults, are warranted to confirm or refute this possible association.