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Background <p>Gestational diabetes mellitus (GDM) affects children’s neurodevelopmental processes. However, continuous monitoring of this effect across different child age span is lacking.</p> Study design <p>1438 mother-infant pairs were finally include in the analysis. Data of a 75-g oral glucose tolerance test (OGTT) administered to women at 24–28 weeks of pregnancy was collected. Neurodevelopment in childhood was assessed using the Ages and Stages Questionnaires.</p> Results <p>At the age of 6 months, GDM offspring had higher risk of delays in the fine motor domain [aOR = 1.77 (<i>95%CI</i>:1.08 ~ 2.88)]. At the age of 18 months, maternal GDM was associated with delays in the domains of fine motor [aOR = 1.94 (<i>95%CI</i>:1.01 ~ 3.72)] and fasting plasma glucose and 1-hour post-load glucose (1-h PG) were more strongly associated with neurodevelopmental delays compared to 2-hour post-load glucose (2-h PG).</p> Conclusions <p>The impaired neurophysiological development risk among offspring born to mothers with GDM increased, particularly evident at 18 months of age and more pronounced in girls.</p>

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Effect of gestational diabetes on neurodevelopment outcome of the offsprings- Ma’an shan birth cohort study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月28日

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  • Yidan Cao,
  • Tuyan Fan,
  • Rongrong Lu,
  • Jingjing Liu,
  • Tingting Weng,
  • Kun Huang,
  • Hui Gao,
  • Shuangqin Yan,
  • Guopeng Gao,
  • Fengyu Yang,
  • Fangbiao Tao,
  • Beibei Zhu

摘要

Background

Gestational diabetes mellitus (GDM) affects children’s neurodevelopmental processes. However, continuous monitoring of this effect across different child age span is lacking.

Study design

1438 mother-infant pairs were finally include in the analysis. Data of a 75-g oral glucose tolerance test (OGTT) administered to women at 24–28 weeks of pregnancy was collected. Neurodevelopment in childhood was assessed using the Ages and Stages Questionnaires.

Results

At the age of 6 months, GDM offspring had higher risk of delays in the fine motor domain [aOR = 1.77 (95%CI:1.08 ~ 2.88)]. At the age of 18 months, maternal GDM was associated with delays in the domains of fine motor [aOR = 1.94 (95%CI:1.01 ~ 3.72)] and fasting plasma glucose and 1-hour post-load glucose (1-h PG) were more strongly associated with neurodevelopmental delays compared to 2-hour post-load glucose (2-h PG).

Conclusions

The impaired neurophysiological development risk among offspring born to mothers with GDM increased, particularly evident at 18 months of age and more pronounced in girls.