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Purpose <p>To report a clinical case of silicone oil-induced toxic posterior segment syndrome (TPSS) after rhegmatogenous retinal detachment (RRD) surgery.</p> Case description <p>A 75-year-old female developed TPSS with retinal hemorrhage and vessel sheathing after 25-G pars plana vitrectomy with silicone oil tamponade for left-eye RRD, had recurrent RRD after silicone oil removal, and achieved complete resolution of inflammation at 1-month follow-up after reoperation with 12% C₃F₈ gas tamponade instead of silicone oil, with laboratory tests confirming silicone oil-induced intense intraocular inflammation.</p> Conclusion <p>Silicone oil can induce early postoperative toxic posterior segment syndrome (TPSS), and 12% C₃F₈ inert gas is a viable alternative tamponade material for such cases.</p>

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Toxic posterior segment syndrome induced by silicone oil tamponade after surgery for rhegmatogenous retinal detachment: a case report

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月16日

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  • Yihong Ding,
  • Jing Hou

摘要

Purpose

To report a clinical case of silicone oil-induced toxic posterior segment syndrome (TPSS) after rhegmatogenous retinal detachment (RRD) surgery.

Case description

A 75-year-old female developed TPSS with retinal hemorrhage and vessel sheathing after 25-G pars plana vitrectomy with silicone oil tamponade for left-eye RRD, had recurrent RRD after silicone oil removal, and achieved complete resolution of inflammation at 1-month follow-up after reoperation with 12% C₃F₈ gas tamponade instead of silicone oil, with laboratory tests confirming silicone oil-induced intense intraocular inflammation.

Conclusion

Silicone oil can induce early postoperative toxic posterior segment syndrome (TPSS), and 12% C₃F₈ inert gas is a viable alternative tamponade material for such cases.