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Background <p>Myelin oligodendrocyte glycoprotein-associated disease (MOGAD) is an inflammatory neurological disorder rarely associated with autoimmune disorders. We report the first case of MOGAD-associated optic neuritis in an Asian patient with psoriasis vulgaris and psoriatic arthritis.</p> Case presentation <p>A 53-year-old female with psoriasis vulgaris and psoriatic arthritis presented with bilateral optic neuritis. She was treated with intravenous methylprednisolone 1&#xa0;g/day for three days, followed by a three-month oral prednisolone taper. The patient experienced near-complete visual recovery and remained relapse-free until present.</p> Conclusions <p>Although rare, this case highlights the importance of recognizing MOGAD-associated optic neuritis in autoimmune patients, as prompt diagnosis and treatment can significantly improve outcomes.</p>

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Coexistence of MOG-IgG-associated bilateral optic neuritis with psoriasis vulgaris and psoriatic arthritis in an Asian patient: a rare case report

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  • 发表日期：

    2026年2月21日

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  • Chia-Wei Chang,
  • Hsiu-Mei Huang,
  • Nai-Wen Tsai,
  • Shang-Hung Lin,
  • Jong-Jer Lee,
  • Yu-Ting Hsiao

摘要

Background

Myelin oligodendrocyte glycoprotein-associated disease (MOGAD) is an inflammatory neurological disorder rarely associated with autoimmune disorders. We report the first case of MOGAD-associated optic neuritis in an Asian patient with psoriasis vulgaris and psoriatic arthritis.

Case presentation

A 53-year-old female with psoriasis vulgaris and psoriatic arthritis presented with bilateral optic neuritis. She was treated with intravenous methylprednisolone 1 g/day for three days, followed by a three-month oral prednisolone taper. The patient experienced near-complete visual recovery and remained relapse-free until present.

Conclusions

Although rare, this case highlights the importance of recognizing MOGAD-associated optic neuritis in autoimmune patients, as prompt diagnosis and treatment can significantly improve outcomes.