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Purpose <p>To evaluate the anatomical, functional, and vascular effects of intravitreal aflibercept in macular telangiectasia (MacTel) type 1 using optical coherence tomography angiography (OCTA).</p> Methods <p>This retrospective study included nine eyes of nine patients with MacTel type 1 who underwent a single intravitreal aflibercept injection. Best-corrected visual acuity (BCVA), central macular thickness (CMT), and macular vessel density in superficial and deep capillary plexuses (SVD and DVD, respectively) were measured before and one month after treatment using swept-source OCT and OCTA.</p> Results <p>Mean BCVA improved from 0.4 ± 0.3 to 0.2 ± 0.2 logMAR (<i>p</i> = 0.003) and CMT decreased from 371.4 ± 112 to 237.9 ± 55.1&#xa0;μm (<i>p</i> = 0.003). Temporal SVD (<i>p</i> = 0.021) and temporal DVD (<i>p</i> = 0.020) showed statistically significant increase. BCVA change showed a strong positive correlation with CMT change (ρ = 0.70, <i>p</i> = 0.034). A moderate negative correlation between the change in BCVA (logMAR) and the change in inferior DVD did not achieve statistical significance (ρ= -0.635, <i>p</i> = 0.066).</p> Conclusion <p>A single intravitreal aflibercept injection led to significant anatomical and functional improvements in MacTel type 1, with a marked increase in vessel density in the temporal quadrant. This study indicates that the characteristics of retinal microvasculature may be modified following aflibercept injection in MacTel type 1 eyes, as observed through OCTA.</p>

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Evaluation of aflibercept treatment outcomes using optical coherence tomography angiography in macular telangiectasia type 1

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月23日

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  • Tuğba Aydoğan Gezginaslan,
  • Yunus Emre Tüzün,
  • Erdinç Bozkurt,
  • Utku Limon,
  • Betül İlkay Sezgin Akçay

摘要

Purpose

To evaluate the anatomical, functional, and vascular effects of intravitreal aflibercept in macular telangiectasia (MacTel) type 1 using optical coherence tomography angiography (OCTA).

Methods

This retrospective study included nine eyes of nine patients with MacTel type 1 who underwent a single intravitreal aflibercept injection. Best-corrected visual acuity (BCVA), central macular thickness (CMT), and macular vessel density in superficial and deep capillary plexuses (SVD and DVD, respectively) were measured before and one month after treatment using swept-source OCT and OCTA.

Results

Mean BCVA improved from 0.4 ± 0.3 to 0.2 ± 0.2 logMAR (p = 0.003) and CMT decreased from 371.4 ± 112 to 237.9 ± 55.1 μm (p = 0.003). Temporal SVD (p = 0.021) and temporal DVD (p = 0.020) showed statistically significant increase. BCVA change showed a strong positive correlation with CMT change (ρ = 0.70, p = 0.034). A moderate negative correlation between the change in BCVA (logMAR) and the change in inferior DVD did not achieve statistical significance (ρ= -0.635, p = 0.066).

Conclusion

A single intravitreal aflibercept injection led to significant anatomical and functional improvements in MacTel type 1, with a marked increase in vessel density in the temporal quadrant. This study indicates that the characteristics of retinal microvasculature may be modified following aflibercept injection in MacTel type 1 eyes, as observed through OCTA.