Scholarlink

Purpose <p>To quantitatively analyze trabecular meshwork (TM) pigmentation in patients with unilateral Fuchs Uveitis Syndrome (FUS) and to compare the findings with those of the healthy fellow eyes.</p> Methods <p>This cross-sectional study included patients with unilateral FUS. Demographic and ophthalmological data were recorded. Gonioscopic photographs of the anterior chamber angle of both eyes were taken under standardized conditions from the superior and inferior TM regions, using the same slit-lamp biomicroscope equipped with a mounted digital camera. TM pigmentation was quantitatively analyzed in the superior, inferior, and total (superior + inferior) regions using ImageJ software.</p> Results <p>Of the 30 patients with unilateral FUS, 5 were excluded due to poor image quality. The remaining 25 patients were analyzed, with FUS eyes classified as the FUS group and fellow eyes as controls. The mean age was 49.0 ± 12.3 years (range: 24–64); 60% were female. Common findings in FUS eyes included vitritis (100%), posterior subcapsular cataract (96%), stellate keratic precipitates (80%), and diffuse iris atrophy (80%). Heterochromia was observed in 40% of patients. Mean intraocular pressure (IOP) did not differ significantly between groups (<i>p</i> = 0.182). TM pigmentation was higher in the FUS group across all regions, reaching statistical significance in the superior and total measurements (<i>p</i> = 0.006 and <i>p</i> = 0.040, respectively). TM pigmentation was lower in all regions in eyes with heterochromia compared to those without, with total values significantly reduced (<i>p</i> = 0.036). No significant correlation was found between IOP and TM pigmentation in the FUS group (<i>p</i> &gt; 0.05).</p> Conclusion <p>This study demonstrated increased TM pigmentation in eyes affected by FUS, which may be due to ongoing pigment release. Conversely, eyes with heterochromia showed reduced pigmentation, likely reflecting chronic pigment loss.This quantitative method may aid in better understanding pigment distribution and iris changes in FUS, providing clinicians with a more objective assessment tool.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Quantitative evaluation of trabecular meshwork pigmentation in unilateral Fuchs uveitis syndrome

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月18日

查看全文
  • Kubra Ozdemir Yalcinsoy,
  • Mehmet Murat Uzel

摘要

Purpose

To quantitatively analyze trabecular meshwork (TM) pigmentation in patients with unilateral Fuchs Uveitis Syndrome (FUS) and to compare the findings with those of the healthy fellow eyes.

Methods

This cross-sectional study included patients with unilateral FUS. Demographic and ophthalmological data were recorded. Gonioscopic photographs of the anterior chamber angle of both eyes were taken under standardized conditions from the superior and inferior TM regions, using the same slit-lamp biomicroscope equipped with a mounted digital camera. TM pigmentation was quantitatively analyzed in the superior, inferior, and total (superior + inferior) regions using ImageJ software.

Results

Of the 30 patients with unilateral FUS, 5 were excluded due to poor image quality. The remaining 25 patients were analyzed, with FUS eyes classified as the FUS group and fellow eyes as controls. The mean age was 49.0 ± 12.3 years (range: 24–64); 60% were female. Common findings in FUS eyes included vitritis (100%), posterior subcapsular cataract (96%), stellate keratic precipitates (80%), and diffuse iris atrophy (80%). Heterochromia was observed in 40% of patients. Mean intraocular pressure (IOP) did not differ significantly between groups (p = 0.182). TM pigmentation was higher in the FUS group across all regions, reaching statistical significance in the superior and total measurements (p = 0.006 and p = 0.040, respectively). TM pigmentation was lower in all regions in eyes with heterochromia compared to those without, with total values significantly reduced (p = 0.036). No significant correlation was found between IOP and TM pigmentation in the FUS group (p > 0.05).

Conclusion

This study demonstrated increased TM pigmentation in eyes affected by FUS, which may be due to ongoing pigment release. Conversely, eyes with heterochromia showed reduced pigmentation, likely reflecting chronic pigment loss.This quantitative method may aid in better understanding pigment distribution and iris changes in FUS, providing clinicians with a more objective assessment tool.