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Background <p>Tamoxifen retinopathy (TAM-R) typically occurs with prolonged and high-dose administration. This study presents an uncommon instance of severe TAM-R following 3.75 years of low-dose tamoxifen (10&#xa0;mg/day) treatment, totaling 450&#xa0;mg cumulatively.</p> Case report <p>A 35-year-old female with obesity (BMI 47.86&#xa0;kg/m²) presented with bilateral vision loss. Multimodal imaging (OCT/OCTA/FFA/FAF) revealed retinal crystal deposition, macular pseudocyst, ellipsoid layer rupture, and deep capillary plexus loss. Despite discontinuation of medication, visual acuity remained poor (BCVA of 20/125 in the right eye and 20/667 in the left eye). At the 10-month follow-up, there was partial structural improvement, yet ellipsoid layer impairment persisted.</p> Conclusion <p>This case challenges traditional TAM-R dosage thresholds, suggesting obesity may exacerbate toxicity. Baseline OCTA vascular markers correlate with irreversible visual impairment, offering novel insights for prognostic evaluation.</p>

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Severe retinopathy induced by low-dose tamoxifen: a 10-month follow-up analysis based on multimodal imaging

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月26日

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  • Shaochi Zhang,
  • Yuanru Wang,
  • Yang Liu,
  • Xiaolong Qi,
  • Xiao Zhang,
  • Xianglian He

摘要

Background

Tamoxifen retinopathy (TAM-R) typically occurs with prolonged and high-dose administration. This study presents an uncommon instance of severe TAM-R following 3.75 years of low-dose tamoxifen (10 mg/day) treatment, totaling 450 mg cumulatively.

Case report

A 35-year-old female with obesity (BMI 47.86 kg/m²) presented with bilateral vision loss. Multimodal imaging (OCT/OCTA/FFA/FAF) revealed retinal crystal deposition, macular pseudocyst, ellipsoid layer rupture, and deep capillary plexus loss. Despite discontinuation of medication, visual acuity remained poor (BCVA of 20/125 in the right eye and 20/667 in the left eye). At the 10-month follow-up, there was partial structural improvement, yet ellipsoid layer impairment persisted.

Conclusion

This case challenges traditional TAM-R dosage thresholds, suggesting obesity may exacerbate toxicity. Baseline OCTA vascular markers correlate with irreversible visual impairment, offering novel insights for prognostic evaluation.