Scholarlink

Purpose <p>To evaluate the therapeutic efficacy and clinical feasibility of manual digital meibomian gland compression compared to instrument-assisted mechanical compression in patients with meibomian gland dysfunction (MGD).</p> Methods <p>Medical records of 70 MGD patients treated between January and December 2022 were retrospectively analyzed. Participants were divided into manual (<i>n</i> = 35) and mechanical compression groups (<i>n</i> = 35). Primary outcomes included Ocular Surface Disease Index (OSDI) scores and ocular surface parameters at 2-week follow-up (14 ± 2 days), and 8-week follow-up (56 ± 2 days). Secondary outcomes assessed manipulation pain intensity (Visual Analogue Scale, VAS), treatment duration, and learning curve length.</p> Results <p>Both groups showed significant improvements in OSDI scores, gland plugging, Schirmer I test, and non-invasive break-up time (NIBUT) at both follow-ups (all <i>P</i> &lt; 0.05). The manual group demonstrated earlier meibum quality improvements (2-week follow-up and 8-week follow-up, <i>P</i> &lt; 0.05) compared to mechanical group’s 8-week follow-up improvement (<i>P</i> = 0.01), along with superior lid margin regularity at 8-week follow-up (<i>P</i> = 0.04). Significant intergroup differences favored manual compression in gland plugging (<i>P</i> = 0.02), meibum quality (<i>P</i> = 0.03), and NIBUT (<i>P</i> &lt; 0.001) at 8-week follow-up. Manual compression consistently yielded lower pain scores (all <i>P</i> &lt; 0.001) and required fewer training cases (13 vs. 20).</p> Conclusions <p>Manual digital compression offers effective MGD management with enhanced patient comfort and faster clinical proficiency compared to mechanical methods. Its demonstrated therapeutic advantages support broader clinical implementation.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Evaluating the efficacy and feasibility of manual digital meibomian gland compression in meibomian gland dysfunction

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月14日

查看全文
  • Jingru Wang,
  • Xianxian Luo,
  • Ling Zhang,
  • Wenjian Shi,
  • Feng Zheng,
  • Yingying Gao

摘要

Purpose

To evaluate the therapeutic efficacy and clinical feasibility of manual digital meibomian gland compression compared to instrument-assisted mechanical compression in patients with meibomian gland dysfunction (MGD).

Methods

Medical records of 70 MGD patients treated between January and December 2022 were retrospectively analyzed. Participants were divided into manual (n = 35) and mechanical compression groups (n = 35). Primary outcomes included Ocular Surface Disease Index (OSDI) scores and ocular surface parameters at 2-week follow-up (14 ± 2 days), and 8-week follow-up (56 ± 2 days). Secondary outcomes assessed manipulation pain intensity (Visual Analogue Scale, VAS), treatment duration, and learning curve length.

Results

Both groups showed significant improvements in OSDI scores, gland plugging, Schirmer I test, and non-invasive break-up time (NIBUT) at both follow-ups (all P < 0.05). The manual group demonstrated earlier meibum quality improvements (2-week follow-up and 8-week follow-up, P < 0.05) compared to mechanical group’s 8-week follow-up improvement (P = 0.01), along with superior lid margin regularity at 8-week follow-up (P = 0.04). Significant intergroup differences favored manual compression in gland plugging (P = 0.02), meibum quality (P = 0.03), and NIBUT (P < 0.001) at 8-week follow-up. Manual compression consistently yielded lower pain scores (all P < 0.001) and required fewer training cases (13 vs. 20).

Conclusions

Manual digital compression offers effective MGD management with enhanced patient comfort and faster clinical proficiency compared to mechanical methods. Its demonstrated therapeutic advantages support broader clinical implementation.