Scholarlink

Background <p>Ophthalmia neonatorum (ON) is a common neonatal ocular condition with potentially serious ocular and systemic complications. The spectrum of causative organisms varies by geographical regions, maternal health practices, and over time. <i>Chlamydia trachomatis</i> remains a significant pathogen with non-specific symptoms that overlap with other infections. This study aims to assess local burden of <i>Chlamydia trachomatis</i> and identify clinical predictors.</p> Methods <p>We conducted a 10-year retrospective review (2014–2023) of neonates presenting with suspected ON at a tertiary paediatric eye centre in Singapore. Clinical and microbiological data were analysed to determine etiological trends and identify predictors of <i>C. trachomatis</i> conjunctivitis. Diagnostic methods included Gram stain, culture, immunofluorescence, and PCR testing. Multivariate logistic regression was used to assess associations.</p> Results <p>A total of 797 neonates were included; 140 (17.5%) tested positive for <i>Chlamydia trachomatis</i> followed by <i>Staphylococcus aureus</i> (10.2%) and MRSA (4.1%), while <i>Neisseria gonorrhoeae</i> was rare (0.75%). Ten-year trend showed a consistent pattern with <i>Chlamydia trachomatis</i> been the highest causative organism followed by Methicillin-sensitive <i>Staphylococcus aureus</i>. The presence of bloody discharge was the strongest predictor for Chlamydia infection (OR = 20.99, 95% CI: 6.09–72.29, <i>p</i> &lt; .001), followed by vaginal delivery (OR = 17.63, 95% CI: 5.59–55.51, <i>p</i> &lt; .001). Additional significant predictors included eyelid swelling (OR = 3.04, 95% CI: 1.58–5.83, <i>p</i> &lt; .001) and conjunctival redness (OR = 2.73, 95% CI: 1.73–4.29, <i>p</i> &lt; .001).</p> Conclusions <p><i>Chlamydia trachomatis</i> remains the leading cause of ON in our cohort. Key clinical predictors—bloody discharge, eyelid swelling, conjunctival redness, and unilateral involvement—can assist clinicians in early recognition and timely initiation of targeted testing and therapy. These findings support the development of predictive diagnostic frameworks in settings with limited access to molecular diagnostics.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Predictors of Chlamydia trachomatis conjunctivitis in neonates: a 10-Year retrospective study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月8日

查看全文
  • Saadia Zohra Farooqui,
  • Shazia Khan,
  • Silpi Biswas

摘要

Background

Ophthalmia neonatorum (ON) is a common neonatal ocular condition with potentially serious ocular and systemic complications. The spectrum of causative organisms varies by geographical regions, maternal health practices, and over time. Chlamydia trachomatis remains a significant pathogen with non-specific symptoms that overlap with other infections. This study aims to assess local burden of Chlamydia trachomatis and identify clinical predictors.

Methods

We conducted a 10-year retrospective review (2014–2023) of neonates presenting with suspected ON at a tertiary paediatric eye centre in Singapore. Clinical and microbiological data were analysed to determine etiological trends and identify predictors of C. trachomatis conjunctivitis. Diagnostic methods included Gram stain, culture, immunofluorescence, and PCR testing. Multivariate logistic regression was used to assess associations.

Results

A total of 797 neonates were included; 140 (17.5%) tested positive for Chlamydia trachomatis followed by Staphylococcus aureus (10.2%) and MRSA (4.1%), while Neisseria gonorrhoeae was rare (0.75%). Ten-year trend showed a consistent pattern with Chlamydia trachomatis been the highest causative organism followed by Methicillin-sensitive Staphylococcus aureus. The presence of bloody discharge was the strongest predictor for Chlamydia infection (OR = 20.99, 95% CI: 6.09–72.29, p < .001), followed by vaginal delivery (OR = 17.63, 95% CI: 5.59–55.51, p < .001). Additional significant predictors included eyelid swelling (OR = 3.04, 95% CI: 1.58–5.83, p < .001) and conjunctival redness (OR = 2.73, 95% CI: 1.73–4.29, p < .001).

Conclusions

Chlamydia trachomatis remains the leading cause of ON in our cohort. Key clinical predictors—bloody discharge, eyelid swelling, conjunctival redness, and unilateral involvement—can assist clinicians in early recognition and timely initiation of targeted testing and therapy. These findings support the development of predictive diagnostic frameworks in settings with limited access to molecular diagnostics.