Background <p>To analyze demographics, incidence, and prevalence of globe injury repair mechanisms in the TriNetX United States population from 2013 to 2023.</p> Methods <p>Retrospective cohort study of globe injury repair mechanisms in the TriNetX United States Collaborative Network database from 2013 to 2023. CPT codes from the ICD-10 classification system were utilized to identify repair methods for globe injuries (65275, 65280, 65285, 65286). Demographics were analyzed using two-factor ANOVA for age and chi-squared tests for race, ethnicity, and sex. Incidence and prevalence were analyzed yearly and cumulatively.</p> Results <p>Of the 119,347,853 subjects in TriNetX, 231,286 cases of globe injuries were identified. Demographics varied by repair category for age and sex ratios. An ANOVA showed a significant difference between age distribution over the four subtypes (mean age 47.2 ± 21.6 years, <i>p</i> &lt; 0.001). The most common procedure was repair of non-perforating corneal lacerations with or without foreign body removal (<i>n</i> = 182,193) and was the only cohort with a female-predominant population (<i>n</i> = 119,990; 65.89%). Chi-squared tests revealed significant differences by sex (<i>p</i> &lt; 0.001), ethnicity (<i>p</i> &lt; 0.001), and race (<i>p</i> &lt; 0.001). Incidence showed variation from 2013 to 2019; however, a large decrease in incidence was noted from 2019 to 2021.</p> Conclusions <p>Our findings align with previous research indicating decreased globe injury incidence during the SARS-CoV-2 pandemic, except for perforating corneal and/or scleral lacerations without uveal tissue involvement. Our study reveals a shift towards higher affected female population than previous literature.</p>