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Background <p>The purpose of our prospective study is to investigate the histopathology of Muller’s muscle extracted after Muller’s Muscle-Conjunctival Resection (MMCR) and to find the relationship between histopathological findings and the outcomes of ptosis surgery.</p> Methods <p>Forty-seven patients with mild to moderate ptosis underwent MMCR surgery and pathological samples including conjunctiva and Muller’s muscle were stained with Hematoxylin and Eosin (H/E) and Masson trichrome. The degree of muscle fibrosis and hypertrophy were evaluated.</p> Results <p>The results indicated that an increase in the severity of fibrosis (for example, increase from mild to moderate), increases the 1&#xa0;mm correction effect by 0.027 (CI = 0.002–0.052 and <i>p</i>-value = 0.033). There is no association between the 1&#xa0;mm correction effect (<i>p</i>-value = 0.67), ptosis correction (<i>p</i>-value = 0.60), and post-operation difference between ptotic and normal eye (<i>p</i>-value = 0.90) with Muller’s muscle hypertrophy. Also, there is no statistically significant association between Muller’s muscle hypertrophy and 1&#xa0;mm correction effect, ptosis correction, and post-operation difference according to the type of pathogenesis (aponeurotic; <i>p</i>-value = 0.123, congenital; <i>p</i>-value = 0.286, horner syndrome; <i>p</i>-value = 0.667).</p> Conclusions <p>Following the increase in Muller’s muscle fibrosis, the ptosis correction effect of MMCR surgery increases, but the presence or absence of hypertrophy of Muller’s muscle is not correlated to the outcomes of surgery.</p>

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Muller’s muscle fibrosis is a possible predictive factor in the outcome of Muller’s muscle-conjunctival resection

  • 期刊论文

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  • 发表日期：

    2025年5月12日

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  • Hassan Asadigandomani,
  • Mohammad Taher Rajabi,
  • Navid Mohsenzadeh Kermani,
  • Zohreh Nozarian,
  • Mohammadreza Ghaedamini,
  • Seyed Mohsen Rafizadeh

摘要

Background

The purpose of our prospective study is to investigate the histopathology of Muller’s muscle extracted after Muller’s Muscle-Conjunctival Resection (MMCR) and to find the relationship between histopathological findings and the outcomes of ptosis surgery.

Methods

Forty-seven patients with mild to moderate ptosis underwent MMCR surgery and pathological samples including conjunctiva and Muller’s muscle were stained with Hematoxylin and Eosin (H/E) and Masson trichrome. The degree of muscle fibrosis and hypertrophy were evaluated.

Results

The results indicated that an increase in the severity of fibrosis (for example, increase from mild to moderate), increases the 1 mm correction effect by 0.027 (CI = 0.002–0.052 and p-value = 0.033). There is no association between the 1 mm correction effect (p-value = 0.67), ptosis correction (p-value = 0.60), and post-operation difference between ptotic and normal eye (p-value = 0.90) with Muller’s muscle hypertrophy. Also, there is no statistically significant association between Muller’s muscle hypertrophy and 1 mm correction effect, ptosis correction, and post-operation difference according to the type of pathogenesis (aponeurotic; p-value = 0.123, congenital; p-value = 0.286, horner syndrome; p-value = 0.667).

Conclusions

Following the increase in Muller’s muscle fibrosis, the ptosis correction effect of MMCR surgery increases, but the presence or absence of hypertrophy of Muller’s muscle is not correlated to the outcomes of surgery.