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Background <p>Infectious agents such as the Epstein-Barr virus are responsible for 10% of gastric carcinomas worldwide. The lake zone in Tanzania lies in an Epstein-Barr virus-endemic (EBV) belt, and the contribution of EBV-related gastric carcinoma has not yet been established. Therefore, this study aimed to investigate the prevalence, staining pattern and clinicopathological features of EBV-related gastric carcinoma at Bugando Medical Center.</p> Methods <p>This was a cross-sectional study conducted at Bugando Medical Center. Latent membrane protein-1, stained on formalin-fixed paraffin-embedded (FFPE) tissue blocks, to determine the prevalence and staining pattern of EBV-associated Gastric carcinoma. Data was entered and cleaned in Excel and then analyzed using STATA version 15. The Chi-square tests were used to assess associations at a significant level of <i>p</i> &lt; 0.05.</p> Results <p>A total of 119 cases were evaluated, with 70 (58.8%) males and 49 (41.2%) females. The prevalence of LMP-1 overexpression was 48(40.3%). LMP-1 positive cases were significantly associated with age 45–60 years, poor differentiation and diffuse histological type. The expression pattern was predominantly nuclear in 37(77.1%), while 11(22.9%) were nuclear and cytoplasmic.</p> Conclusions <p>Gastric carcinoma in our setting showed a high level of LMP-1 overexpression. These findings suggest that all patients aged 45–60 years, with poorly differentiated carcinoma and diffuse histological type, should be screened for LMP-1 overexpression as a predictive marker for targeted therapy and favorable prognostication.</p>

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Staining pattern and clinicopathological features of Epstein-Barr virus, Latent Membrane protein 1 expression in patients with gastric carcinoma in Lake zone, Tanzania

  • 期刊论文

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  • 发表日期：

    2026年5月29日

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  • Athuman Chalamila,
  • Edrick Elias,
  • Oscar Ottoman,
  • Subira Matiku,
  • Cosmas Mbulwa,
  • Jackson Kahima,
  • Idd Shabani,
  • Aroan Orgenes,
  • Alex Mremi,
  • Peter Rambau

摘要

Background

Infectious agents such as the Epstein-Barr virus are responsible for 10% of gastric carcinomas worldwide. The lake zone in Tanzania lies in an Epstein-Barr virus-endemic (EBV) belt, and the contribution of EBV-related gastric carcinoma has not yet been established. Therefore, this study aimed to investigate the prevalence, staining pattern and clinicopathological features of EBV-related gastric carcinoma at Bugando Medical Center.

Methods

This was a cross-sectional study conducted at Bugando Medical Center. Latent membrane protein-1, stained on formalin-fixed paraffin-embedded (FFPE) tissue blocks, to determine the prevalence and staining pattern of EBV-associated Gastric carcinoma. Data was entered and cleaned in Excel and then analyzed using STATA version 15. The Chi-square tests were used to assess associations at a significant level of p < 0.05.

Results

A total of 119 cases were evaluated, with 70 (58.8%) males and 49 (41.2%) females. The prevalence of LMP-1 overexpression was 48(40.3%). LMP-1 positive cases were significantly associated with age 45–60 years, poor differentiation and diffuse histological type. The expression pattern was predominantly nuclear in 37(77.1%), while 11(22.9%) were nuclear and cytoplasmic.

Conclusions

Gastric carcinoma in our setting showed a high level of LMP-1 overexpression. These findings suggest that all patients aged 45–60 years, with poorly differentiated carcinoma and diffuse histological type, should be screened for LMP-1 overexpression as a predictive marker for targeted therapy and favorable prognostication.