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Background <p>The clinical benefits of cluster of differentiation 30 (CD30)-target chimeric antigen receptor T-cell (CAR-T) therapy in patients with lymphoma remain controversial. This meta-analysis intended to comprehensively investigate the efficacy and safety of CD30-targeted CAR-T therapy in these patients.</p> Methods <p>Studies on CD30-targeted CAR-T therapy for patients with lymphoma were searched comprehensively in Web of Science, PubMed, Embase, and Cochrane Library databases until March 2025. A single-arm meta-analysis was performed to calculate pooled proportions with 95% confidence intervals (CI). Heterogeneity was assessed using the I² statistic, and fixed- or random-effects models were applied accordingly. Efficacy and safety outcomes were extracted and analyzed.</p> Results <p>A total of seven studies containing 102 cases were included in this meta-analysis. The pooled rates (95% CI) of complete response, partial response, stable disease, and progressive disease were 43.5% (17.6%; 69.3%), 17.5% (3.0%; 31.9%), 17.8% (3.0%; 32.6%), 10.7% (4.8%; 16.6%), respectively. The pooled objective response rate (95% CI) and disease control rate (95% CI) were 66.1% (46.4%; 85.9%) and 89.3% (83.4%; 95.2%). Regarding safety results, the pooled incidences (95% CI) of cytokine release syndrome, nausea or vomiting, anemia, and thrombocytopenia were 57.7% (37.7%; 77.8%), 38.2% (11.3%; 65.1%), 79.1% (48.0%; 100.0%), and 70.2% (36.1%; 100.0%), respectively. No publication bias was observed in any outcome measures (all <i>P</i> &gt; 0.05). Quality assessment showed that all included studies were of moderate-to-high quality. Moreover, sensitivity analyses exhibited high robustness of results.</p> Conclusion <p>CD30-targeted CAR-T therapy demonstrates promising objective response rates with manageable toxicities in patients with lymphoma. The findings of this meta-analysis provide preliminary descriptive evidence to inform future clinical research and exploratory application of CD30-targeted CAR-T therapy in lymphoma.</p>

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Efficacy and safety of CD30-targeted chimeric antigen receptor T-cell therapy for lymphoma: a meta-analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月25日

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  • Jixiang Shi,
  • Cong Lu,
  • Chao Song,
  • Qian Wang

摘要

Background

The clinical benefits of cluster of differentiation 30 (CD30)-target chimeric antigen receptor T-cell (CAR-T) therapy in patients with lymphoma remain controversial. This meta-analysis intended to comprehensively investigate the efficacy and safety of CD30-targeted CAR-T therapy in these patients.

Methods

Studies on CD30-targeted CAR-T therapy for patients with lymphoma were searched comprehensively in Web of Science, PubMed, Embase, and Cochrane Library databases until March 2025. A single-arm meta-analysis was performed to calculate pooled proportions with 95% confidence intervals (CI). Heterogeneity was assessed using the I² statistic, and fixed- or random-effects models were applied accordingly. Efficacy and safety outcomes were extracted and analyzed.

Results

A total of seven studies containing 102 cases were included in this meta-analysis. The pooled rates (95% CI) of complete response, partial response, stable disease, and progressive disease were 43.5% (17.6%; 69.3%), 17.5% (3.0%; 31.9%), 17.8% (3.0%; 32.6%), 10.7% (4.8%; 16.6%), respectively. The pooled objective response rate (95% CI) and disease control rate (95% CI) were 66.1% (46.4%; 85.9%) and 89.3% (83.4%; 95.2%). Regarding safety results, the pooled incidences (95% CI) of cytokine release syndrome, nausea or vomiting, anemia, and thrombocytopenia were 57.7% (37.7%; 77.8%), 38.2% (11.3%; 65.1%), 79.1% (48.0%; 100.0%), and 70.2% (36.1%; 100.0%), respectively. No publication bias was observed in any outcome measures (all P > 0.05). Quality assessment showed that all included studies were of moderate-to-high quality. Moreover, sensitivity analyses exhibited high robustness of results.

Conclusion

CD30-targeted CAR-T therapy demonstrates promising objective response rates with manageable toxicities in patients with lymphoma. The findings of this meta-analysis provide preliminary descriptive evidence to inform future clinical research and exploratory application of CD30-targeted CAR-T therapy in lymphoma.