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Background <p>As a novel inflammatory-nutritional biomarker, the C-reactive protein–albumin–lymphocyte (CALLY) index has demonstrated significant prognostic value in several cancer types. However, its predictive significance for patients with locally advanced non-small cell lung cancer (LA-NSCLC) treated with thoracic radiotherapy (RT) remains elusive. This study aimed to investigate the relationship between the pre/post-treatment CALLY index and the prognosis of patients with LA-NSCLC treated with thoracic RT.</p> Methods <p>In this retrospective study, a cohort of 218 LA-NSCLC patients who underwent thoracic RT between 2012 and 2018 was assessed. The calculation of CALLY involved the use of C-reactive protein (CRP) level, albumin level, and lymphocyte count. Cox proportional hazards regression and the Kaplan-Meier survival analyses were employed to analyze the relationships between various variables and overall survival (OS), local progression-free survival (LPFS), and distant metastasis-free survival (DMFS).</p> Results <p>Multivariate Cox analysis revealed that post-treatment CALLY values were significantly associated with OS, LPFS, and DMFS. Patients with lower post-treatment CALLY values exhibited poorer survival outcomes compared with those with higher CALLY values.</p> Conclusions <p>These findings demonstrate that the post-treatment CALLY index could be a valuable tool for predicting prognosis and guiding subsequent treatment strategies in patients with LA-NSCLC undergoing thoracic RT. Further prospective studies are warranted to validate these results and to explore the potential of incorporating the CALLY index into clinical decision-making.</p>

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Prognostic value of CALLY index in patients with locally advanced non-small cell lung cancer treated with thoracic radiotherapy

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月24日

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  • Xiaoming Yin,
  • Xinying He,
  • Wei Guo,
  • Hongling Lu,
  • Haijun Chen,
  • Rujing Huang,
  • Tingting Hu,
  • Li Xiao,
  • Yunchuan Sun,
  • Kui Fan

摘要

Background

As a novel inflammatory-nutritional biomarker, the C-reactive protein–albumin–lymphocyte (CALLY) index has demonstrated significant prognostic value in several cancer types. However, its predictive significance for patients with locally advanced non-small cell lung cancer (LA-NSCLC) treated with thoracic radiotherapy (RT) remains elusive. This study aimed to investigate the relationship between the pre/post-treatment CALLY index and the prognosis of patients with LA-NSCLC treated with thoracic RT.

Methods

In this retrospective study, a cohort of 218 LA-NSCLC patients who underwent thoracic RT between 2012 and 2018 was assessed. The calculation of CALLY involved the use of C-reactive protein (CRP) level, albumin level, and lymphocyte count. Cox proportional hazards regression and the Kaplan-Meier survival analyses were employed to analyze the relationships between various variables and overall survival (OS), local progression-free survival (LPFS), and distant metastasis-free survival (DMFS).

Results

Multivariate Cox analysis revealed that post-treatment CALLY values were significantly associated with OS, LPFS, and DMFS. Patients with lower post-treatment CALLY values exhibited poorer survival outcomes compared with those with higher CALLY values.

Conclusions

These findings demonstrate that the post-treatment CALLY index could be a valuable tool for predicting prognosis and guiding subsequent treatment strategies in patients with LA-NSCLC undergoing thoracic RT. Further prospective studies are warranted to validate these results and to explore the potential of incorporating the CALLY index into clinical decision-making.