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Objectives <p>This study assesses the prognostic value of the controlling nutritional status score (CONUT) in colorectal cancer patients.</p> Methods <p>A systematic search was performed in PubMed, Embase, Web of Science, and Cochrane databases until December 2024. The primary outcomes were overall survival (OS), disease-free survival (DFS), and relapse-free survival (RFS). Hazard ratios (HR) with 95% confidence intervals (CI) were used for data synthesis. Sensitivity and subgroup analyses were used to assess the results stability and heterogeneity sources. All statistical analyses were performed using Review Manager 5.4 and STATA 15.1.</p> Results <p>Fifteen studies involving 9,258 colorectal cancer patients were included. Meta-analysis showed higher CONUT scores were linked to shorter OS (HR: 2.12; 95% CI: 1.70–2.65; <i>P</i> &lt; 0.00001), DFS (HR: 1.71; 95% CI: 1.11–2.64; <i>P</i> = 0.02), and RFS (HR: 1.75; 95% CI: 1.39–2.20; <i>P</i> &lt; 0.00001). Sensitivity analysis confirmed the stability of CONUT’s prognostic value for OS, DFS, and RFS. Subgroup analysis identified the CONUT cut-off value as a major factor contributing to OS heterogeneity.</p> Conclusions <p>CONUT appears to be associated with worse prognosis in colorectal cancer patients. However, due to potential publication bias, heterogeneity, and the retrospective study design, further large-scale, multicenter, prospective cohort studies are required to confirm its prognostic utility.</p>

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Prognostic value of controlling nutritional status score (CONUT) in patients with colorectal cancer: a systematic review and meta-analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月5日

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  • Weiwei Gu,
  • Hong Li

摘要

Objectives

This study assesses the prognostic value of the controlling nutritional status score (CONUT) in colorectal cancer patients.

Methods

A systematic search was performed in PubMed, Embase, Web of Science, and Cochrane databases until December 2024. The primary outcomes were overall survival (OS), disease-free survival (DFS), and relapse-free survival (RFS). Hazard ratios (HR) with 95% confidence intervals (CI) were used for data synthesis. Sensitivity and subgroup analyses were used to assess the results stability and heterogeneity sources. All statistical analyses were performed using Review Manager 5.4 and STATA 15.1.

Results

Fifteen studies involving 9,258 colorectal cancer patients were included. Meta-analysis showed higher CONUT scores were linked to shorter OS (HR: 2.12; 95% CI: 1.70–2.65; P < 0.00001), DFS (HR: 1.71; 95% CI: 1.11–2.64; P = 0.02), and RFS (HR: 1.75; 95% CI: 1.39–2.20; P < 0.00001). Sensitivity analysis confirmed the stability of CONUT’s prognostic value for OS, DFS, and RFS. Subgroup analysis identified the CONUT cut-off value as a major factor contributing to OS heterogeneity.

Conclusions

CONUT appears to be associated with worse prognosis in colorectal cancer patients. However, due to potential publication bias, heterogeneity, and the retrospective study design, further large-scale, multicenter, prospective cohort studies are required to confirm its prognostic utility.