Scholarlink

Background <p>While sarcopenia is associated with adverse pancreatic cancer (PC) outcomes, prospective evidence linking muscle health to PC risk remains limited. This study aimed to prospectively investigate the associations of grip strength and muscle mass with incident PC risk in the UK Biobank cohort.</p> Methods <p>Among 363,693 UK Biobank participants, grip strength (kg) and bioelectrical impedance analysis (BIA)-derived muscle mass (weight-normalized) were measured. Cox proportional hazards models, adjusted for age, sex, lifestyle factors, and metabolic syndrome components, assessed PC risk over a median 13.7-year follow-up.</p> Results <p>Higher muscle mass (HR = 0.86, 95% Confidential Interval [CI]:0.78–0.95) and grip strength (HR = 0.90, 95% CI:0.83–0.98) demonstrated linear inverse associations with PC risk showing sex-specific divergence: muscle mass reduction conferred stronger protection in men (HR = 0.84, 95% CI:0.74–0.96), whereas grip strength showed greater impact in women (HR = 0.84, 95% CI:0.74–0.96). Subgroup analyses revealed that improved grip strength reduced PC risk in diabetics (HR = 0.89, 95% CI:0.80–0.99), while obese individuals benefited from both enhanced grip strength (HR = 0.95, 95% CI:0.90–0.99) and muscle mass (HR = 0.88, 95% CI:0.82–0.94). Population-attributable fraction estimates suggest 5–12% of PC cases could be prevented through muscle health interventions.</p> Conclusion <p>These findings highlight an association between improved physical capability and reduced PC risk, supporting the adoption of sex-specific preventive strategies—prioritizing muscle mass augmentation in men and grip strength enhancement in women, particularly in high-risk metabolic subgroups. By characterizing sarcopenia as an independent risk factor, this study underscores the imperative to integrate muscle preservation into pancreatic cancer prevention paradigms.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Muscle strength and mass as predictors of pancreatic cancer: insights from the UK biobank

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年8月20日

查看全文
  • Xin Liu,
  • Hui Song,
  • Chao Li,
  • Xiao Hu,
  • Chang Li,
  • Guo-tao Lu,
  • Hongfei Xiang,
  • Qian Yu

摘要

Background

While sarcopenia is associated with adverse pancreatic cancer (PC) outcomes, prospective evidence linking muscle health to PC risk remains limited. This study aimed to prospectively investigate the associations of grip strength and muscle mass with incident PC risk in the UK Biobank cohort.

Methods

Among 363,693 UK Biobank participants, grip strength (kg) and bioelectrical impedance analysis (BIA)-derived muscle mass (weight-normalized) were measured. Cox proportional hazards models, adjusted for age, sex, lifestyle factors, and metabolic syndrome components, assessed PC risk over a median 13.7-year follow-up.

Results

Higher muscle mass (HR = 0.86, 95% Confidential Interval [CI]:0.78–0.95) and grip strength (HR = 0.90, 95% CI:0.83–0.98) demonstrated linear inverse associations with PC risk showing sex-specific divergence: muscle mass reduction conferred stronger protection in men (HR = 0.84, 95% CI:0.74–0.96), whereas grip strength showed greater impact in women (HR = 0.84, 95% CI:0.74–0.96). Subgroup analyses revealed that improved grip strength reduced PC risk in diabetics (HR = 0.89, 95% CI:0.80–0.99), while obese individuals benefited from both enhanced grip strength (HR = 0.95, 95% CI:0.90–0.99) and muscle mass (HR = 0.88, 95% CI:0.82–0.94). Population-attributable fraction estimates suggest 5–12% of PC cases could be prevented through muscle health interventions.

Conclusion

These findings highlight an association between improved physical capability and reduced PC risk, supporting the adoption of sex-specific preventive strategies—prioritizing muscle mass augmentation in men and grip strength enhancement in women, particularly in high-risk metabolic subgroups. By characterizing sarcopenia as an independent risk factor, this study underscores the imperative to integrate muscle preservation into pancreatic cancer prevention paradigms.