Scholarlink

Background <p>Red blood cell disorders have been implicated in tumorigenesis. Nevertheless, the association between red cell indices (RCIs), which reflect the health status of red blood cells, and the risk of cancer has yet to be determined.</p> Methods <p>This was a prospective cohort study involving 455,897 participants who were free of cancer at baseline and had measurements of RCIs, namely mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), red cell distribution width (RDW), and hemoglobin (Hb). The associations of RCIs with overall and site-specific cancer risk were examined by using multivariate Cox proportional hazards regression models with RCIs mutually adjusted. The dose–response relationships were investigated via restricted cubic splines.</p> Results <p>Over a median follow-up of 10.9&#xa0;years, 47,177 participants were diagnosed with cancer. MCV (Q5 vs Q1: fully-adjusted HR = 0.83, 95% CI: 0.78–0.88) and MCH (HR = 0.83, 95% CI: 0.79–0.87) exhibited a non-linear and inverse association with the overall cancer risk (both <i>P</i> values for nonlinear &lt; 0.001). Conversely, RDW showed a linear and positive association with the overall cancer risk (HR = 1.19, 95% CI: 1.15–1.23, <i>P</i> for linear &lt; 0.001). For site-specific cancers, MCV and MCH exhibited inverse associations with the risks of lymphoma, leukemia, breast cancer, and kidney cancer, while RDW was positively associated with the risks of these malignancies.</p> Conclusions <p>Our findings indicate that MCV, MCH, and RDW have clinical significance as potential biomarkers for predicting cancer risk. Further studies are needed to elucidate the underlying mechanisms driving these associations.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Red cell indices as predictors of cancer risk: findings from a large prospective cohort study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年8月20日

查看全文
  • Chengqu Fu,
  • Xueni Cheng,
  • Yuefan Shen,
  • Xinyi Liu,
  • Jianv Huang,
  • Weiwei Chen,
  • Lu He,
  • Yingying Mao,
  • Wei Zhao,
  • Yekun Deng,
  • Dong Hang

摘要

Background

Red blood cell disorders have been implicated in tumorigenesis. Nevertheless, the association between red cell indices (RCIs), which reflect the health status of red blood cells, and the risk of cancer has yet to be determined.

Methods

This was a prospective cohort study involving 455,897 participants who were free of cancer at baseline and had measurements of RCIs, namely mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), red cell distribution width (RDW), and hemoglobin (Hb). The associations of RCIs with overall and site-specific cancer risk were examined by using multivariate Cox proportional hazards regression models with RCIs mutually adjusted. The dose–response relationships were investigated via restricted cubic splines.

Results

Over a median follow-up of 10.9 years, 47,177 participants were diagnosed with cancer. MCV (Q5 vs Q1: fully-adjusted HR = 0.83, 95% CI: 0.78–0.88) and MCH (HR = 0.83, 95% CI: 0.79–0.87) exhibited a non-linear and inverse association with the overall cancer risk (both P values for nonlinear < 0.001). Conversely, RDW showed a linear and positive association with the overall cancer risk (HR = 1.19, 95% CI: 1.15–1.23, P for linear < 0.001). For site-specific cancers, MCV and MCH exhibited inverse associations with the risks of lymphoma, leukemia, breast cancer, and kidney cancer, while RDW was positively associated with the risks of these malignancies.

Conclusions

Our findings indicate that MCV, MCH, and RDW have clinical significance as potential biomarkers for predicting cancer risk. Further studies are needed to elucidate the underlying mechanisms driving these associations.