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Background <p>Inflammatory signaling is linked with cancer-related cognitive impairment (CRCI), potentially through modulation of brain-derived neurotrophic factor (BDNF) expression. Here, we evaluate associations between plasma cytokines and BDNF and their relationship with cognition in a longitudinal study of adolescent and young adult cancer patients (AYAC) receiving chemotherapy and non-cancer controls (NC) (Clinicaltrials.gov: NCT03476070).</p> Methods <p>Newly diagnosed AYAC (15–39&#xa0;years old) and age-matched NC completed the Functional Assessment of Cancer Therapy-Cognitive Function questionnaire (FACT‐Cog), the Cambridge Neuropsychological Test Automated Battery (CANTAB), and blood draws every 3–6&#xa0;months up to 12&#xa0;months (AYAC) or 6&#xa0;months (NC) from baseline. Plasma levels of cytokines and BDNF were quantified using a multiplexed immunoassay and ELISA, respectively. Biomarker-cognition and cytokine-BDNF associations were analyzed using mixed-effects models with interactions for chemotherapy status for AYAC (during chemotherapy vs. &gt; 30&#xa0;days post-chemotherapy).</p> Results <p>One-hundred and seventy-seven participants were included, with 66 AYAC and 111 NC. AYAC had a higher frequency of clinically significant cognitive impairment during and post-chemotherapy compared to NC. In trends unique to AYAC, higher IL-10 was associated with better self-perceived cognition, IL-8 with better multi-tasking, IL-6 with worse multi-tasking, response speed, and attention, and TNF-α with better memory (<i>p</i> &lt; 0.05). Higher BDNF was associated with better memory and response speed (<i>p</i> &lt; 0.05). IL-4, IL-10, TNF-α, and IFN-γ were associated with BDNF levels among AYAC and NC (<i>p</i> &lt; 0.05).</p> Conclusions <p>Our large, age-matched study implicates dysregulated cytokine signaling and altered BDNF expression in CRCI among AYAC during and post-chemotherapy. As precision medicine becomes integrated into AYA patient care, plasma BDNF and cytokines may serve as important predictors of CRCI onset.</p> Trial registration <p>The study was prospectively registered on ClinicalTrials.gov (NCT03476070) on March 3, 2018.</p>

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Brain-derived neurotrophic factor and cytokines as predictors of cognitive impairment in adolescent and young adult cancer patients receiving chemotherapy: a longitudinal study

  • 期刊论文

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  • 发表日期：

    2025年7月1日

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  • Julia Trudeau,
  • Ding Quan Ng,
  • Michael Sayer,
  • Chia Jie Tan,
  • Yu Ke,
  • Raymond J. Chan,
  • Alexandre Chan

摘要

Background

Inflammatory signaling is linked with cancer-related cognitive impairment (CRCI), potentially through modulation of brain-derived neurotrophic factor (BDNF) expression. Here, we evaluate associations between plasma cytokines and BDNF and their relationship with cognition in a longitudinal study of adolescent and young adult cancer patients (AYAC) receiving chemotherapy and non-cancer controls (NC) (Clinicaltrials.gov: NCT03476070).

Methods

Newly diagnosed AYAC (15–39 years old) and age-matched NC completed the Functional Assessment of Cancer Therapy-Cognitive Function questionnaire (FACT‐Cog), the Cambridge Neuropsychological Test Automated Battery (CANTAB), and blood draws every 3–6 months up to 12 months (AYAC) or 6 months (NC) from baseline. Plasma levels of cytokines and BDNF were quantified using a multiplexed immunoassay and ELISA, respectively. Biomarker-cognition and cytokine-BDNF associations were analyzed using mixed-effects models with interactions for chemotherapy status for AYAC (during chemotherapy vs. > 30 days post-chemotherapy).

Results

One-hundred and seventy-seven participants were included, with 66 AYAC and 111 NC. AYAC had a higher frequency of clinically significant cognitive impairment during and post-chemotherapy compared to NC. In trends unique to AYAC, higher IL-10 was associated with better self-perceived cognition, IL-8 with better multi-tasking, IL-6 with worse multi-tasking, response speed, and attention, and TNF-α with better memory (p < 0.05). Higher BDNF was associated with better memory and response speed (p < 0.05). IL-4, IL-10, TNF-α, and IFN-γ were associated with BDNF levels among AYAC and NC (p < 0.05).

Conclusions

Our large, age-matched study implicates dysregulated cytokine signaling and altered BDNF expression in CRCI among AYAC during and post-chemotherapy. As precision medicine becomes integrated into AYA patient care, plasma BDNF and cytokines may serve as important predictors of CRCI onset.

Trial registration

The study was prospectively registered on ClinicalTrials.gov (NCT03476070) on March 3, 2018.