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Background <p>To differentiate inoperable non-small cell lung cancer (NSCLC) subtypes by mono-exponential (MEM), bi-exponential (BEM), and stretched- exponential models (SEM) intravoxel incoherent motion (IVIM), and <sup>18</sup>F-FDG PET parameters.</p> Materials and methods <p>A total of 106 cases of NSCLC were included in this analysis, of which 68 cases were adenocarcinoma (AC) and 38 cases were squamous cell carcinoma (SCC). MEM derived parameter ADC; BEM derived parameters D, D*, and f, SEM derived parameters α, DDC; and <sup>18</sup>F-FDG PET derived parameters MTV, SUV<sub>max</sub>, and TLG were recorded and compared. Area under the receiver operating characteristic curve (AUC) was performed for diagnostic efficacy.</p> Results <p>SUV<sub>max</sub>, MTV and TLG were lower and ADC, f, D and DDC were higher in AC than in SCC (p all &lt; 0.001), whereas D* and α were not significantly different (<i>p</i> = 0.824, 0.152). Logistic regression analysis showed that the stage, ADC, and TLG were independent predictors for identification of SCC and AC, and when combined they showed best diagnostic result (AUC, 0.906; sensitivity, 79.41%; specificity, 94.74%), which was higher than any single clinical factor (maximum diameter, sex smoking, stage, and CT readout; AUC = 0.725, 0.686, 0.707, 0.721, and 0.666, respectively), IVIM (ADC, f, and D; AUC = 0.772, 0.686, and 0.696, respectively) or <sup>18</sup>F-FDG PET-derived variable (SUV<sub>max</sub>, MTV, and TLG; AUC = 0.693, 0.712, and 0.774, respectively).</p> Conclusion <p>The stage, ADC, and TLG were independent predictors for differentiating subtypes of inoperable NSCLC, and when combined they showed optimal diagnostic performance and could be a superior imaging marker.</p>

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Metabolic and multi-model intravoxel incoherent motion parameters based 18F-FDG PET/MRI for predicting subtypes of inoperable non-small cell lung cancer

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月21日

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  • Zhun Huang,
  • Huihui Wang,
  • Fang Ting,
  • Yang Chen,
  • Hengquan Fan,
  • Xiaochen Li,
  • Fangfang Fu,
  • Jianmin Yuan,
  • Yang Yang,
  • Zhe Wang,
  • Meiyun Wang

摘要

Background

To differentiate inoperable non-small cell lung cancer (NSCLC) subtypes by mono-exponential (MEM), bi-exponential (BEM), and stretched- exponential models (SEM) intravoxel incoherent motion (IVIM), and 18F-FDG PET parameters.

Materials and methods

A total of 106 cases of NSCLC were included in this analysis, of which 68 cases were adenocarcinoma (AC) and 38 cases were squamous cell carcinoma (SCC). MEM derived parameter ADC; BEM derived parameters D, D*, and f, SEM derived parameters α, DDC; and 18F-FDG PET derived parameters MTV, SUVmax, and TLG were recorded and compared. Area under the receiver operating characteristic curve (AUC) was performed for diagnostic efficacy.

Results

SUVmax, MTV and TLG were lower and ADC, f, D and DDC were higher in AC than in SCC (p all < 0.001), whereas D* and α were not significantly different (p = 0.824, 0.152). Logistic regression analysis showed that the stage, ADC, and TLG were independent predictors for identification of SCC and AC, and when combined they showed best diagnostic result (AUC, 0.906; sensitivity, 79.41%; specificity, 94.74%), which was higher than any single clinical factor (maximum diameter, sex smoking, stage, and CT readout; AUC = 0.725, 0.686, 0.707, 0.721, and 0.666, respectively), IVIM (ADC, f, and D; AUC = 0.772, 0.686, and 0.696, respectively) or 18F-FDG PET-derived variable (SUVmax, MTV, and TLG; AUC = 0.693, 0.712, and 0.774, respectively).

Conclusion

The stage, ADC, and TLG were independent predictors for differentiating subtypes of inoperable NSCLC, and when combined they showed optimal diagnostic performance and could be a superior imaging marker.