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Objective <p>To evaluate the diagnostic value of Ultrasound-derived fat fraction (UDFF) and Automatic point Shear Wave Elastography (Auto pSWE) for intrahepatic cholestasis of pregnancy (ICP) and preeclampsia (PE).</p> Methods <p>This prospective study included 135 healthy pregnant women and patients with ICP and PE. Data collected included medical history, anthropometry, liver ultrasound, UDFF, Elastic Modulus (E), Shear Wave Velocity (SWV), and biochemical parameters. Each ICP or PE case was matched 1:1 with a healthy control by age (± 2 years) and gestational age (± 1 week). Differences in UDFF, Auto pSWE, and markers of liver and endothelial function were analyzed among ICP, PE, and healthy controls. The diagnostic value of UDFF and Auto pSWE was evaluated using univariate, correlation, and multivariate logistic regression analyses, and sensitivity, specificity, and optimal cutoffs were determined by ROC analysis.</p> Results <p>(1) Significant differences were observed between the ICP and PE groups and the control group in clinical indicators such as BMI, ALT, TBA, T-Bil, PT, and ALB (<i>P</i> &lt; 0.05).(2) UDFF, E, and SWV parameters showed significant differences between the ICP, PE, and control groups (<i>P</i> &lt; 0.01). E was identified as the preferred screening marker for ICP, with an optimal cutoff value of 7.471&#xa0;kPa. UDFF and E were independently associated with PE; however, UDFF showed stronger, moderate-to-good performance for assessing PE severity, while E provided complementary stiffness information.</p> Conclusion <p>UDFF and Auto pSWE non-invasively quantify hepatic fat and stiffness in pregnancy and demonstrate clinically useful accuracy for diagnosing and staging ICP and PE, supporting their role as quantitative screening tools.</p>

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Ultrasound-derived fat fraction and automated point shear-wave elastography in diagnosing intrahepatic cholestasis of pregnancy and preeclampsia

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月16日

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  • Ke-xiong Niu,
  • Jing-jing Ye,
  • Wen-dong Zhang,
  • Bin Ma,
  • Tian-gang Li

摘要

Objective

To evaluate the diagnostic value of Ultrasound-derived fat fraction (UDFF) and Automatic point Shear Wave Elastography (Auto pSWE) for intrahepatic cholestasis of pregnancy (ICP) and preeclampsia (PE).

Methods

This prospective study included 135 healthy pregnant women and patients with ICP and PE. Data collected included medical history, anthropometry, liver ultrasound, UDFF, Elastic Modulus (E), Shear Wave Velocity (SWV), and biochemical parameters. Each ICP or PE case was matched 1:1 with a healthy control by age (± 2 years) and gestational age (± 1 week). Differences in UDFF, Auto pSWE, and markers of liver and endothelial function were analyzed among ICP, PE, and healthy controls. The diagnostic value of UDFF and Auto pSWE was evaluated using univariate, correlation, and multivariate logistic regression analyses, and sensitivity, specificity, and optimal cutoffs were determined by ROC analysis.

Results

(1) Significant differences were observed between the ICP and PE groups and the control group in clinical indicators such as BMI, ALT, TBA, T-Bil, PT, and ALB (P < 0.05).(2) UDFF, E, and SWV parameters showed significant differences between the ICP, PE, and control groups (P < 0.01). E was identified as the preferred screening marker for ICP, with an optimal cutoff value of 7.471 kPa. UDFF and E were independently associated with PE; however, UDFF showed stronger, moderate-to-good performance for assessing PE severity, while E provided complementary stiffness information.

Conclusion

UDFF and Auto pSWE non-invasively quantify hepatic fat and stiffness in pregnancy and demonstrate clinically useful accuracy for diagnosing and staging ICP and PE, supporting their role as quantitative screening tools.