Objective <p>To evaluate systemic immune-inflammatory biomarkers in patients diagnosed with eclampsia and to investigate their potential association with inflammation.</p> Methods <p>This retrospective study included 31 patients with eclampsia and 51 healthy pregnant women matched for age and parity. Hematological biomarkers—including NLR, MLR, PLR, SII, SIRI, PNR, dNLR, and AISI—were calculated using complete blood count data collected prior to delivery. Statistical comparisons between groups were performed using appropriate tests based on data distribution.</p> Results <p>There were no statistically significant differences in NLR, MLR, SII, SIRI, dNLR, or AISI between groups (<i>p</i> &gt; 0.05). The PLR and PNR levels were significantly lower in the eclampsia group (<i>p</i> = 0.021 and <i>p</i> = 0.044). Additionally, the eclampsia group had significantly lower gestational age and neonatal birth weight, and higher rates of cesarean section, ICU admission, and maternal complications (all <i>p</i> &lt; 0.001).</p> Conclusion <p>This study found no significant association between eclampsia and most systemic immune-inflammatory biomarkers. PLR and PNR values were significantly lower in the eclampsia group. These markers may serve as potential negative predictive biomarkers, but their diagnostic value remains limited. Further prospective studies are needed to clarify their clinical utility in eclampsia.</p>