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Background <p>The placenta and umbilical cord play a crucial role in fetal growth, development, and neonatal survival. Although extensively studied in developed countries, quantitative data on placental and umbilical cord morphology in preeclampsia are scarce in Ghana. This study aimed to assess the gross morphometry of preeclamptic placentae and umbilical cords and their relationship with neonatal indices.</p> Method <p>A cross-sectional study was conducted on 152 freshly delivered placentae (100 normotensive; 52 preeclamptic) at the Holy Family Hospital, Berekum, Ghana. Maternal data collected included age, parity, blood pressure, and occupation. Standard anthropometric techniques were used for placental and umbilical cord measurements after they were fixed with 10% neutral buffered formalin. Statistical analyses included t-test, Chi-square, and Spearman correlation, with significance set at <i>p</i> &lt; 0.05.</p> Results <p>Placental and umbilical cord indices differed significantly between preeclamptic and normotensive groups, except for cord length. Moderate to strong correlations were observed between placental and cord indices and neonatal outcomes, but not with neonatal length. Placentae were more often oval, and cords were eccentrically inserted in preeclamptic births compared to normotensive births.</p> Conclusions <p>Preeclampsia is associated with altered placental and umbilical cord morphology and reduced neonatal growth indices. These findings provide baseline data to support multidisciplinary strategies for improved management and pregnancy outcomes in Ghana.</p>

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Placental and umbilical cord morphometry in preeclampsia and their association with neonatal outcomes: a preliminary study in Ghana

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月25日

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  • Rita Agyei Boakye,
  • Nancy Darkoa Darko,
  • Atta Kusi Appiah,
  • Chrissie Stansie Abaidoo,
  • Juliet Robertson,
  • Frank Enoch Gyamfi,
  • Francis Kofi Sarkodie,
  • Ronald Awoonor-Williams,
  • Emmanuel Ansah Owusu

摘要

Background

The placenta and umbilical cord play a crucial role in fetal growth, development, and neonatal survival. Although extensively studied in developed countries, quantitative data on placental and umbilical cord morphology in preeclampsia are scarce in Ghana. This study aimed to assess the gross morphometry of preeclamptic placentae and umbilical cords and their relationship with neonatal indices.

Method

A cross-sectional study was conducted on 152 freshly delivered placentae (100 normotensive; 52 preeclamptic) at the Holy Family Hospital, Berekum, Ghana. Maternal data collected included age, parity, blood pressure, and occupation. Standard anthropometric techniques were used for placental and umbilical cord measurements after they were fixed with 10% neutral buffered formalin. Statistical analyses included t-test, Chi-square, and Spearman correlation, with significance set at p < 0.05.

Results

Placental and umbilical cord indices differed significantly between preeclamptic and normotensive groups, except for cord length. Moderate to strong correlations were observed between placental and cord indices and neonatal outcomes, but not with neonatal length. Placentae were more often oval, and cords were eccentrically inserted in preeclamptic births compared to normotensive births.

Conclusions

Preeclampsia is associated with altered placental and umbilical cord morphology and reduced neonatal growth indices. These findings provide baseline data to support multidisciplinary strategies for improved management and pregnancy outcomes in Ghana.