Scholarlink

Background <p>This umbrella meta-analysis aimed to examine the effect of prenatal vitamin D supplementation on maternal and neonatal outcomes.</p> Methods <p>Scopus and PubMed were searched up to September 2024 to include relevant studies. The outcomes included gestational diabetes mellitus (GDM), preeclampsia, cesarean section, preterm delivery (PTD), low birth weight (LBW), small for gestational age (SGA), stillbirth, neonatal mortality, birth weight, birth length, and head circumference at birth. Standardized mean difference (SMD) and relative risk (RR) with their 95% confidence intervals (CI) were used as effect sizes to pool the data using a random effects model.</p> Results <p>Thirty-five studies with 188,370 participants were included. Vitamin D supplementation lowered the risk of GDM (RR = 0.68, 95%CI: 0.53 to 0.88), preeclampsia (RR = 0.62, 95%CI: 0.56 to 0.69), PTD (RR = 0.77, 95%CI: 0.65 to 0.90), LBW (RR = 0.67, 95%CI: 0.54 to 0.84), SGA (RR = 0.73, 95%CI: 0.63 to 0.85), stillbirth (RR = 0.77, 95%CI: 0.62 to 0.95), and neonatal mortality (RR = 0.58, 95%CI: 0.40 to 0.84), while also enhanced birth weight (SMD = 75.68, 95%CI: 48.99 to 102.36), birth length (SMD = 0.25, 95%CI: 0.18 to 0.33), and head circumference (SMD = 0.15, 95%CI: 0.06 to 0.23). These effects were observed with lower doses of vitamin D ((&lt; 50,000 IU/week), shorter intervention periods (&lt; 14 weeks), and among older participants ((≥ 27 years). Moreover, vitamin D supplementation was linked to the reduced risk of cesarean deliveries in some subgroups.</p> Conclusions <p>Prenatal vitamin D supplementation may be associated with a lower risk of certain adverse maternal and neonatal outcomes and may improve birth anthropometric measurements.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Vitamin D supplementation during pregnancy and maternal and neonatal outcomes: results from a quantitative umbrella meta-analysis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月1日

查看全文
  • Liping Lin,
  • Qijuan Zhu,
  • Yunshan Xiao,
  • Xueqin Zhang

摘要

Background

This umbrella meta-analysis aimed to examine the effect of prenatal vitamin D supplementation on maternal and neonatal outcomes.

Methods

Scopus and PubMed were searched up to September 2024 to include relevant studies. The outcomes included gestational diabetes mellitus (GDM), preeclampsia, cesarean section, preterm delivery (PTD), low birth weight (LBW), small for gestational age (SGA), stillbirth, neonatal mortality, birth weight, birth length, and head circumference at birth. Standardized mean difference (SMD) and relative risk (RR) with their 95% confidence intervals (CI) were used as effect sizes to pool the data using a random effects model.

Results

Thirty-five studies with 188,370 participants were included. Vitamin D supplementation lowered the risk of GDM (RR = 0.68, 95%CI: 0.53 to 0.88), preeclampsia (RR = 0.62, 95%CI: 0.56 to 0.69), PTD (RR = 0.77, 95%CI: 0.65 to 0.90), LBW (RR = 0.67, 95%CI: 0.54 to 0.84), SGA (RR = 0.73, 95%CI: 0.63 to 0.85), stillbirth (RR = 0.77, 95%CI: 0.62 to 0.95), and neonatal mortality (RR = 0.58, 95%CI: 0.40 to 0.84), while also enhanced birth weight (SMD = 75.68, 95%CI: 48.99 to 102.36), birth length (SMD = 0.25, 95%CI: 0.18 to 0.33), and head circumference (SMD = 0.15, 95%CI: 0.06 to 0.23). These effects were observed with lower doses of vitamin D ((< 50,000 IU/week), shorter intervention periods (< 14 weeks), and among older participants ((≥ 27 years). Moreover, vitamin D supplementation was linked to the reduced risk of cesarean deliveries in some subgroups.

Conclusions

Prenatal vitamin D supplementation may be associated with a lower risk of certain adverse maternal and neonatal outcomes and may improve birth anthropometric measurements.