Background <p>Gestational diabetes mellitus (GDM) is associated with various adverse outcomes in pregnancy for the mother and the baby. Precise prediction of GDM trends are crucial for public health. Machine learning (ML) models have emerged as powerful tools for disease prediction, demonstrating superior results compared to traditional methods. As a result, we set out to assess the effectiveness of ML models for predicting GDM.</p> Methods <p>This was a retrospective study that used the clinical and demographic information of all mothers admitted for delivery to a primary referral tertiary center located in Bandar Abbas, Iran, from January 2020 to January 2022. The input data were employed in seven ML models. To evaluate the diagnostic potential of each model, we utilized the accuracy, area under the curve (AUC), precision, recall, and F1 score.</p> Results <p>The incidence rate of GDM was 20.9%. Models utilizing Boosting techniques, particularly CatBoost and XGBoost, excelled in predicting GDM compared to other models, however the prediction power was not high. These two models yielded the best average AUC (approximately 0.64 to 0.66) and also the top average Recall (approximately 0.43 to 0.52). In terms of all performance metrics, CatBoost demonstrated the best capability in predicting GDM with acceptable accuracy and average recall. BMI, maternal age, gestational age, maternal education, maternal residency, fetal gender, history of abortion, and parity were among the top 10 features that highly predicted GDM. Conversely, factors like intrauterine fetal demise, infertility, cardiovascular issues, COVID-19, substance abuse, multiple births, anemia, and a history of stillbirth exhibited nearly zero significance across nearly all models due to their low prevalence or lack of diversity.</p> Conclusion <p>CatBoost model had a higher performance in predicting GDM, however the prediction power was not so high.</p>