Background <p>Although pregnancy is a part of the natural life cycle for every woman, the idea that pregnancy is a happy period and a state of emotional well-being has now been abandoned. This process causes intense changes to woman bodies, minds and society. The study aims to determine how psychological well-being mediates the relationship between psychological health and psychological resilience in expectant women.</p> Methods <p>The study was conducted descriptively with 130 expectant women who attended the obstetrics outpatient clinic at a university hospital between 15.07.2021 and 30.12.2021.</p> Results <p>A moderately significant association between psychosocial health and psychological well-being during pregnancy (<i>p</i> &lt; 0.01), and a moderately strong association between psychological well-being and psychological resilience were found (<i>p</i> &lt; 0.01).</p> <p>Psychosocial health and psychological resilience during pregnancy were also significantly associated at a low-level (<i>p</i>&lt;0.1). The result of the Structural Equation Modeling Mediation analysis reveals that psychological well-being serves as a crucial mediating role in the relationship between psychosocial health and psychological resilience during pregnancy. (β = 0.08, t = 0.61). The model fit indices were determined as X²=237.12.</p> Conclusions <p>The study found that expectant women have an important role in strengthening the association between psychosocial health and psychological well-being through their mediating role of psychological well-being.&#xa0;</p>