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Background <p>Limited clinical research has focused on women with chronic kidney disease (CKD) undergoing assisted reproductive technology (ART). We aim to investigate the kidney outcome and the adverse pregnancy-related outcomes of CKD women after pregnancy with ART.</p> Methods <p>A longitudinal study was conducted, including CKD and non-CKD women who had successful delivered after ART between January 2014 to December 2023. By matching with age and BMI, an optimal full-matching propensity score analysis was performed to select the optimal patients of control at a ratio of 1 to 3. Clinical and laboratory data at the baseline and during the follow-up was collected. The study had received approval from the Ethics Review Board of Sun Yat-sen Memorial Hospital (No. SYSKY-2023–008-01).</p> Results <p>Nineteen CKD women and fifty-seven non-CKD women were included. Before pregnancy, glomerular hematuria (15/19, 78.9%) represented the most common clinical manifestation of the CKD women, while four (21.1%) patients appeared with proteinuria. Pre-existing hypertension occurred in one CKD women (1/19, 5.3%). Meanwhile, most of the patients (18/19, 94.7%) were in stage 1 of CKD and the rest one was in stage 2. No increased risks of ovarian hyperstimulation syndrome, kidney function deterioration, adverse maternal outcomes and adverse neonatal outcomes were observed in CKD group compared with the control.</p> Conclusions <p>Based on our findings, ART appears to be as safe for women with early-stage CKD and low risk of disease progression, in terms of pregnancy complications and kidney function, as it is for the general female population.</p>

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Impact of assisted reproductive therapy on kidney and pregnancy outcomes in women with early-stage chronic kidney disease: a longitudinal analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月10日

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  • Ziqing Gao,
  • Lin Li,
  • Pengwei Chen,
  • Jianan Su,
  • Qiongqiong Yang,
  • Min Feng

摘要

Background

Limited clinical research has focused on women with chronic kidney disease (CKD) undergoing assisted reproductive technology (ART). We aim to investigate the kidney outcome and the adverse pregnancy-related outcomes of CKD women after pregnancy with ART.

Methods

A longitudinal study was conducted, including CKD and non-CKD women who had successful delivered after ART between January 2014 to December 2023. By matching with age and BMI, an optimal full-matching propensity score analysis was performed to select the optimal patients of control at a ratio of 1 to 3. Clinical and laboratory data at the baseline and during the follow-up was collected. The study had received approval from the Ethics Review Board of Sun Yat-sen Memorial Hospital (No. SYSKY-2023–008-01).

Results

Nineteen CKD women and fifty-seven non-CKD women were included. Before pregnancy, glomerular hematuria (15/19, 78.9%) represented the most common clinical manifestation of the CKD women, while four (21.1%) patients appeared with proteinuria. Pre-existing hypertension occurred in one CKD women (1/19, 5.3%). Meanwhile, most of the patients (18/19, 94.7%) were in stage 1 of CKD and the rest one was in stage 2. No increased risks of ovarian hyperstimulation syndrome, kidney function deterioration, adverse maternal outcomes and adverse neonatal outcomes were observed in CKD group compared with the control.

Conclusions

Based on our findings, ART appears to be as safe for women with early-stage CKD and low risk of disease progression, in terms of pregnancy complications and kidney function, as it is for the general female population.