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Purpose <p>To investigate whether vitamin B12 levels affect IVF-ET pregnancy outcomes.</p> Design <p>Single-center, retrospective, observational study.</p> Design <p>Single-center, retrospective, observational study.</p> Main outcome measures <p>The primary outcome was the clinical pregnancy rate (CPR).</p> Results <p>After adjusting for Age, BMI, AMH, number of oocytes retrieved, cleavage-stage embryos/blastocysts, and the number of transferred embryos, when the vitamin B12 value was ≤358.7 pg/ml, for every 10 pg/ml increase in the vitamin B12 value, the clinical pregnancy rate increased by 4% (OR=1.04, 95% CI=1.00, 1.08, P=0.03).</p> Conclusion <p>Within a specific range (≤358.7 pg/mL), serum vitamin B12 levels may modestly contribute to improved clinical pregnancy rates in women undergoing IVF-ET with the follicular-phase GnRH agonist protocol, though further validation is required to confirm its clinical significance.</p> Trial registration <p>None.</p>

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Does vitamin B12 influence clinical pregnancy outcome in the follicular-phase GnRH agonist protocol?

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月21日

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  • Xiaoning Wang,
  • Kui Fu,
  • Ying Zhang,
  • Shengfang Jiang,
  • Changjun Zhang

摘要

Purpose

To investigate whether vitamin B12 levels affect IVF-ET pregnancy outcomes.

Design

Single-center, retrospective, observational study.

Design

Single-center, retrospective, observational study.

Main outcome measures

The primary outcome was the clinical pregnancy rate (CPR).

Results

After adjusting for Age, BMI, AMH, number of oocytes retrieved, cleavage-stage embryos/blastocysts, and the number of transferred embryos, when the vitamin B12 value was ≤358.7 pg/ml, for every 10 pg/ml increase in the vitamin B12 value, the clinical pregnancy rate increased by 4% (OR=1.04, 95% CI=1.00, 1.08, P=0.03).

Conclusion

Within a specific range (≤358.7 pg/mL), serum vitamin B12 levels may modestly contribute to improved clinical pregnancy rates in women undergoing IVF-ET with the follicular-phase GnRH agonist protocol, though further validation is required to confirm its clinical significance.

Trial registration

None.