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Introduction <p>Gestational Trophoblastic Disease (GTD) encompasses a spectrum of placenta-related disorders with significant health risks. Despite the varying reported prevalence rates in East Africa, no comprehensive meta-analysis has been conducted to synthesize the overall burden and predictors of GTD in this region.</p> Methods <p>Following the PRISMA guidelines, we conducted a systematic review and meta-analysis of studies from PubMed, Cochrane Library, and Google Scholar (search period: 2000–2024). We assessed heterogeneity (I<sup>2</sup> and Q tests), pooled estimates using a random-effects model, and evaluated publication bias using funnel plots and Egger’s test. A sensitivity analysis was performed to test the robustness of the findings.</p> Results <p>Eleven studies were included, revealing a pooled GTD magnitude of 10.5% (95% CI: 8.8–12.3; I<sup>2</sup> = 100%, <i>p</i> &lt; 0.001). Significant predictors included prior GTD history (AOR = 3.2, 95% CI: 0.6–5.7; I<sup>2</sup> = 75.2%, <i>p</i> = 0.018) and grand multiparity (AOR = 8.9, 95% CI: 2.8–15.1; I<sup>2</sup> = 76%, <i>p</i> = 0.041). Subgroup analysis showed that complete molar pregnancies (37.8%, 95% CI: 5.9–69.8) were more prevalent than partial molar pregnancies (11.8%, 95% CI: 9.7–13.9), both with high heterogeneity (I<sup>2</sup> = 100%, <i>p</i> &lt; 0.001).</p> Conclusion <p>Gestational trophoblastic disease remains a significant public health burden in East Africa, where delayed healthcare access contributes to worsened outcomes. Women with a history of gestational trophoblastic disease or high parity constitute high-risk populations that require targeted screening programs and early intervention strategies to improve their detection and management.</p>

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Magnitude and predictors of gestational trophoblastic disease in East Africa: a systematic review and meta-analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月30日

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  • Gizachew Yilak,
  • Befkad Derese Tilahun,
  • Amsalu Baylie Taye,
  • Bogale Molla,
  • Addisu Getie,
  • Dejen Tsegaye,
  • Mulat Ayele,
  • Eyob Shitie Lake

摘要

Introduction

Gestational Trophoblastic Disease (GTD) encompasses a spectrum of placenta-related disorders with significant health risks. Despite the varying reported prevalence rates in East Africa, no comprehensive meta-analysis has been conducted to synthesize the overall burden and predictors of GTD in this region.

Methods

Following the PRISMA guidelines, we conducted a systematic review and meta-analysis of studies from PubMed, Cochrane Library, and Google Scholar (search period: 2000–2024). We assessed heterogeneity (I2 and Q tests), pooled estimates using a random-effects model, and evaluated publication bias using funnel plots and Egger’s test. A sensitivity analysis was performed to test the robustness of the findings.

Results

Eleven studies were included, revealing a pooled GTD magnitude of 10.5% (95% CI: 8.8–12.3; I2 = 100%, p < 0.001). Significant predictors included prior GTD history (AOR = 3.2, 95% CI: 0.6–5.7; I2 = 75.2%, p = 0.018) and grand multiparity (AOR = 8.9, 95% CI: 2.8–15.1; I2 = 76%, p = 0.041). Subgroup analysis showed that complete molar pregnancies (37.8%, 95% CI: 5.9–69.8) were more prevalent than partial molar pregnancies (11.8%, 95% CI: 9.7–13.9), both with high heterogeneity (I2 = 100%, p < 0.001).

Conclusion

Gestational trophoblastic disease remains a significant public health burden in East Africa, where delayed healthcare access contributes to worsened outcomes. Women with a history of gestational trophoblastic disease or high parity constitute high-risk populations that require targeted screening programs and early intervention strategies to improve their detection and management.