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Background <p>First trimester prediction of fetal growth restriction (FGR) remain suboptimal. We aimed to search for new circulating angiogenic biomarkers for improvement.</p> Methods <p>This case-control study compared 73 singleton pregnancies with early or late-onset FGR based on Delphi consensus and 73 matched normal controls. Their maternal serum samples stored during 11–13 weeks were retrieved for measurement of 36 angiogenic biomarkers by MILLIPLEX<sup>®</sup> human angiogenesis magnetic bead panels. Those biomarkers that showed significant differences between the study groups were further analysed with receiver operating characteristic (ROC) curve.</p> Results <p>In the early-onset FGR group, log<sub>10</sub>MoM of soluble neuropilin-1 (sNRP-1: 0.08 ± 0.11 vs. 0.00 ± 0.09, <i>P</i> &lt; 0.001) and log<sub>10</sub>MoM of soluble platelet and endothelial cell adhesion molecule 1 (sPECAM-1: 0.05 ± 0.06 vs. 0.00 ± 0.09, <i>P</i> &lt; 0.05) were significantly higher than the control group, while log<sub>10</sub>MoM of platelet-derived growth factor AB/BB (PDGF-AB/BB: -0.08 ± 0.13 vs. 0.00 ± 0.16, <i>P</i> &lt; 0.05) and PAPP-A (-0.15 ± 0.28 vs. 0.05 ± 0.23, <i>P</i> &lt; 0.001) were lower. Their combination achieved the highest area under the ROC curve (AUC) of 0.83 (95% CI: 0.74–0.95) with a higher sensitivity than that of PAPP-A alone (61.5% vs. 30.8% at 10% false positive rate, <i>P</i> &lt; 0.001). Concerning the late-onset FGR group, only log<sub>10</sub>MoMs of sFlt-1 (-0.12 vs. 0.00, <i>P</i> &lt; 0.001) and PAPP-A (-0.07 vs. 0.05, <i>P</i> &lt; 0.05) were lower than the control group, but their AUC was only 0.68 (95% CI:0.59–0.78).</p> Conclusions <p>Three new first trimester biomarkers, sNRP-1, sPECAM-1 and PDGF-AB/BB are predictive of subsequent development of early-onset FGR.</p>

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New first trimester circulating angiogenic biomarkers in predicting early-onset and late-onset fetal growth restriction: a case-control study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月10日

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  • Xiaoyi Bai,
  • Wei Li,
  • Wenjing Ding,
  • Oi Ka Chan,
  • Maran Bo Wah Leung,
  • So Ling Lau,
  • Daljit Singh Sahota,
  • Chi Chiu Wang,
  • Tak Yeung Leung

摘要

Background

First trimester prediction of fetal growth restriction (FGR) remain suboptimal. We aimed to search for new circulating angiogenic biomarkers for improvement.

Methods

This case-control study compared 73 singleton pregnancies with early or late-onset FGR based on Delphi consensus and 73 matched normal controls. Their maternal serum samples stored during 11–13 weeks were retrieved for measurement of 36 angiogenic biomarkers by MILLIPLEX® human angiogenesis magnetic bead panels. Those biomarkers that showed significant differences between the study groups were further analysed with receiver operating characteristic (ROC) curve.

Results

In the early-onset FGR group, log10MoM of soluble neuropilin-1 (sNRP-1: 0.08 ± 0.11 vs. 0.00 ± 0.09, P < 0.001) and log10MoM of soluble platelet and endothelial cell adhesion molecule 1 (sPECAM-1: 0.05 ± 0.06 vs. 0.00 ± 0.09, P < 0.05) were significantly higher than the control group, while log10MoM of platelet-derived growth factor AB/BB (PDGF-AB/BB: -0.08 ± 0.13 vs. 0.00 ± 0.16, P < 0.05) and PAPP-A (-0.15 ± 0.28 vs. 0.05 ± 0.23, P < 0.001) were lower. Their combination achieved the highest area under the ROC curve (AUC) of 0.83 (95% CI: 0.74–0.95) with a higher sensitivity than that of PAPP-A alone (61.5% vs. 30.8% at 10% false positive rate, P < 0.001). Concerning the late-onset FGR group, only log10MoMs of sFlt-1 (-0.12 vs. 0.00, P < 0.001) and PAPP-A (-0.07 vs. 0.05, P < 0.05) were lower than the control group, but their AUC was only 0.68 (95% CI:0.59–0.78).

Conclusions

Three new first trimester biomarkers, sNRP-1, sPECAM-1 and PDGF-AB/BB are predictive of subsequent development of early-onset FGR.