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Background <p>Limited research has examined the potential association between triglyceride glucose-body mass index (TyG-BMI) and gestational diabetes mellitus (GDM). The objective of this investigation was to analyze this linkage and evaluate TyG-BMI’s capability to predict GDM.</p> Methods <p>This research employed secondary data derived from a prospective cohort in South Korea, which included 588 pregnant women with singleton gestations, collected between November 2014 and July 2016. To investigate the connection between TyG-BMI and GDM, logistic regression and sensitivity analyses were performed. Furthermore, an analysis of receiver operating characteristics (ROC) was conducted to assess the prognostic accuracy of TyG-BMI in relation to GDM.</p> Results <p>The cohort exhibited a mean age of 32.07 ± 3.80 years, with 36 individuals (6.12%) manifesting GDM during the interval of 24 to 28 weeks of gestation. Following the adjustment for possible confounding variables, an increased TyG-BMI was associated with an elevated risk of GDM, as indicated by an odds ratio (OR) of 1.02 (95% CI: 1.01–1.04). Additionally, the area under the curve (AUC) for TyG-BMI’s predictive performance was recorded at 0.7979 (0.7143–0.8814), with an optimal threshold established at 211.03, which resulted in a specificity of 86.23% and a sensitivity of 66.67%.</p> Conclusions <p>In this South Korean cohort, increased TyG-BMI during early pregnancy (10–14 weeks) was significantly associated with the onset of GDM (during pregnancy 24–28 weeks). TyG-BMI could be integrated into clinical practice as a complementary preliminary screening tool for detecting women who are at increased risk of GDM.</p>

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Association between triglyceride glucose-body mass index and gestational diabetes mellitus: a prospective cohort study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月17日

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  • Xiaomin Liang,
  • Kai Lai,
  • Xiaohong Li,
  • Di Ren,
  • Shuiqing Gui,
  • Ying Li,
  • Zemao Xing

摘要

Background

Limited research has examined the potential association between triglyceride glucose-body mass index (TyG-BMI) and gestational diabetes mellitus (GDM). The objective of this investigation was to analyze this linkage and evaluate TyG-BMI’s capability to predict GDM.

Methods

This research employed secondary data derived from a prospective cohort in South Korea, which included 588 pregnant women with singleton gestations, collected between November 2014 and July 2016. To investigate the connection between TyG-BMI and GDM, logistic regression and sensitivity analyses were performed. Furthermore, an analysis of receiver operating characteristics (ROC) was conducted to assess the prognostic accuracy of TyG-BMI in relation to GDM.

Results

The cohort exhibited a mean age of 32.07 ± 3.80 years, with 36 individuals (6.12%) manifesting GDM during the interval of 24 to 28 weeks of gestation. Following the adjustment for possible confounding variables, an increased TyG-BMI was associated with an elevated risk of GDM, as indicated by an odds ratio (OR) of 1.02 (95% CI: 1.01–1.04). Additionally, the area under the curve (AUC) for TyG-BMI’s predictive performance was recorded at 0.7979 (0.7143–0.8814), with an optimal threshold established at 211.03, which resulted in a specificity of 86.23% and a sensitivity of 66.67%.

Conclusions

In this South Korean cohort, increased TyG-BMI during early pregnancy (10–14 weeks) was significantly associated with the onset of GDM (during pregnancy 24–28 weeks). TyG-BMI could be integrated into clinical practice as a complementary preliminary screening tool for detecting women who are at increased risk of GDM.