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Background <p>The aim of this study is to explore the relationship of inflammatory indicators with the severity and prognosis of neurological dysfunction in stroke patients, and to evaluate the prognostic value of inflammatory indicators for patients suffering from acute ischemic stroke (AIS).</p> Methods <p>The study recruited 225 AIS patients and 46 healthy individuals, and collected their clinical data and hematological indicators. Calculate six inflammatory markers and evaluate the National Institutes of Health Stroke Scale (NIHSS) and Modified Rankin Scale (mRS) scores at admission, discharge, 1 months of onset and 3 months of onset. Correlation analysis, multivariate logistic regression analyses, the receiver operating characteristic (ROC) curve and the area under the curve (AUC) were used to analyze the relationship of inflammatory markers with the severity and prognosis of stroke.</p> Results <p>Elevated levels of neutrophil to lymphocyte ratio (NLR), systemic immune-inflammation index (SII), systemic inflammatory response index (SIRI), and pan immune-inflammation value (PIV) were observed in patients at admission (<i>p</i> &lt; 0.05). Most inflammatory markers are positively correlated with the severity of neurological deficits during the acute phase, especially upon admission and discharge. Higher admission lymphocyte to monocyte ratio (LMR) levels are independently associated with larger infarct volume and adverse functional outcomes. In contrast, indicators like NLR, SIRI and PIV showed associations in the opposite direction (odds ratios &lt; 1), suggesting complex interactions that require further investigation. For different time points, NLR showed the greatest prognostic value at admission (AUC = 0.654) and PIV at discharge (AUC = 0.725).</p> Conclusions <p>These inflammatory markers exhibit characteristic dynamic changes after AIS and have close relationship with the severity and prognosis of neurological deficits. It may contribute to early risk stratification and personalized treatment soon after.</p>

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The relationship between inflammatory markers and the severity and prognosis of neurological dysfunction in stroke patients

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月18日

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  • Xile Zhang,
  • Luyu li,
  • Qing Lin,
  • Yu Xiao,
  • Yani Dong,
  • Xiaoxiao Tao,
  • Yong Wang

摘要

Background

The aim of this study is to explore the relationship of inflammatory indicators with the severity and prognosis of neurological dysfunction in stroke patients, and to evaluate the prognostic value of inflammatory indicators for patients suffering from acute ischemic stroke (AIS).

Methods

The study recruited 225 AIS patients and 46 healthy individuals, and collected their clinical data and hematological indicators. Calculate six inflammatory markers and evaluate the National Institutes of Health Stroke Scale (NIHSS) and Modified Rankin Scale (mRS) scores at admission, discharge, 1 months of onset and 3 months of onset. Correlation analysis, multivariate logistic regression analyses, the receiver operating characteristic (ROC) curve and the area under the curve (AUC) were used to analyze the relationship of inflammatory markers with the severity and prognosis of stroke.

Results

Elevated levels of neutrophil to lymphocyte ratio (NLR), systemic immune-inflammation index (SII), systemic inflammatory response index (SIRI), and pan immune-inflammation value (PIV) were observed in patients at admission (p < 0.05). Most inflammatory markers are positively correlated with the severity of neurological deficits during the acute phase, especially upon admission and discharge. Higher admission lymphocyte to monocyte ratio (LMR) levels are independently associated with larger infarct volume and adverse functional outcomes. In contrast, indicators like NLR, SIRI and PIV showed associations in the opposite direction (odds ratios < 1), suggesting complex interactions that require further investigation. For different time points, NLR showed the greatest prognostic value at admission (AUC = 0.654) and PIV at discharge (AUC = 0.725).

Conclusions

These inflammatory markers exhibit characteristic dynamic changes after AIS and have close relationship with the severity and prognosis of neurological deficits. It may contribute to early risk stratification and personalized treatment soon after.