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Introduction <p>The study aims to investigate associations between markers of atrial cardiopathy and cognitive function trajectories in adults without prior AF.</p> Methods <p>The study included 4,486 participants from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study. Markers of atrial cardiopathy included atrial premature complexes and N-Terminal pro-Brain Natriuretic Peptide (NT pro-BNP). Cognitive status was measured using the Six-Item Screener (SIS). Cognitive status trajectories were identified using latent class growth models.</p> Results <p>Three unique cognitive trajectories over the 8-year follow-up were identified: 86.7% showed a normal and stable trajectory of SIS score, 7.6% showed a progressively decreasing trajectory, and 5.7% showed a dramatic decreasing trajectory. Age, black participants, and antidepression drugs were significantly associated with the “dramatic decrease” trajectory. Elevated NT pro-BNP was significantly associated with the “dramatic decrease” trajectory.</p> Discussion <p>Markers of left atrial cardiopathy may have implications for early diagnosis and prevention of cognitive impairment.</p>

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Markers of left atrial cardiopathy and cognitive function trajectories in adults aged ≥ 45 years without atrial fibrillation: a population-based study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月21日

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  • Zhe Li,
  • Danielle Marion,
  • Jessica Blair,
  • Elsayed Z. Soliman,
  • David Gladstone,
  • Hooman Kamel,
  • David Birnie,
  • Doug Manuel,
  • Frederick W. Unverzagt,
  • Virginia Howard,
  • Jodi D. Edwards

摘要

Introduction

The study aims to investigate associations between markers of atrial cardiopathy and cognitive function trajectories in adults without prior AF.

Methods

The study included 4,486 participants from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study. Markers of atrial cardiopathy included atrial premature complexes and N-Terminal pro-Brain Natriuretic Peptide (NT pro-BNP). Cognitive status was measured using the Six-Item Screener (SIS). Cognitive status trajectories were identified using latent class growth models.

Results

Three unique cognitive trajectories over the 8-year follow-up were identified: 86.7% showed a normal and stable trajectory of SIS score, 7.6% showed a progressively decreasing trajectory, and 5.7% showed a dramatic decreasing trajectory. Age, black participants, and antidepression drugs were significantly associated with the “dramatic decrease” trajectory. Elevated NT pro-BNP was significantly associated with the “dramatic decrease” trajectory.

Discussion

Markers of left atrial cardiopathy may have implications for early diagnosis and prevention of cognitive impairment.