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Background <p>We report a compelling case of neurosarcoidosis in a 74-year-old Japanese woman. She initially presented with a clinical course that closely mimicked Guillain-Barré syndrome (GBS), and the definitive diagnosis of neurosarcoidosis was eventually made through a skin biopsy.</p> Case presentation <p>The patient presented with progressive limb weakness and sensory disturbances and was initially treated for a presumptive diagnosis of GBS. Although her condition showed an initial temporary improvement, her symptoms subsequently relapsed and worsened. This atypical and relapsing clinical pattern prompted a comprehensive systemic workup to find an alternative diagnosis. Based on the histological findings on skin biopsy and the clinical presentation, a diagnosis of probable neurosarcoidosis was made.</p> Conclusion <p>This case highlights the importance of considering neurosarcoidosis in the differential diagnosis of GBS with an atypical course. A comprehensive systemic workup is crucial for such cases. It further emphasizes that a thorough systemic evaluation is essential for accurate diagnosis, as a simple and accessible procedure like a skin biopsy can provide essential histological evidence to support the diagnosis.</p>

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A case report of neurosarcoidosis mimicking Guillain-Barré syndrome: the diagnostic utility of skin biopsy in neurosarcoidosis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月19日

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  • Kaede Ishikawa,
  • Kazuhiro Horiuchi,
  • Sho Saika,
  • Shuntaro Nakamura,
  • Sumire Nunomura,
  • Kazuki Yamada,
  • Masaaki Yoshikawa,
  • Haruki Koike,
  • Ichiro Yabe

摘要

Background

We report a compelling case of neurosarcoidosis in a 74-year-old Japanese woman. She initially presented with a clinical course that closely mimicked Guillain-Barré syndrome (GBS), and the definitive diagnosis of neurosarcoidosis was eventually made through a skin biopsy.

Case presentation

The patient presented with progressive limb weakness and sensory disturbances and was initially treated for a presumptive diagnosis of GBS. Although her condition showed an initial temporary improvement, her symptoms subsequently relapsed and worsened. This atypical and relapsing clinical pattern prompted a comprehensive systemic workup to find an alternative diagnosis. Based on the histological findings on skin biopsy and the clinical presentation, a diagnosis of probable neurosarcoidosis was made.

Conclusion

This case highlights the importance of considering neurosarcoidosis in the differential diagnosis of GBS with an atypical course. A comprehensive systemic workup is crucial for such cases. It further emphasizes that a thorough systemic evaluation is essential for accurate diagnosis, as a simple and accessible procedure like a skin biopsy can provide essential histological evidence to support the diagnosis.