Scholarlink

Background <p>Craniopharyngiomas, benign tumors of the sellar region, frequently disrupt hypothalamic function, leading to endocrine and neurological sequelae, including sleep disorders.</p> Case presentation <p>This case highlights the diagnostic and therapeutic challenges of secondary narcolepsy in a 19-year-old woman with craniopharyngioma. The patient presented with excessive daytime sleepiness, prolonged sleep duration, no cataplexy, and cognitive dysfunction following tumor treatment. However, CSF level of orexin/hypocretin was not measured. Diagnosis of secondary narcolepsy was confirmed through overnight polysomnography and multiple sleep latency tests. Combining methylphenidate for wakefulness and donepezil for cognitive support led to symptomatic improvement. </p> Conclusions <p>This case underscores the necessity of recognizing secondary narcolepsy in patients with hypothalamic dysfunction and tailoring multidisciplinary management strategies to optimize outcomes.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Secondary narcolepsy and cognitive dysfunction related to craniopharyngioma: a case study

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月15日

查看全文
  • Amelia Nur Vidyanti,
  • Atika Rahmadini,
  • Rifki Habibi Rahman,
  • Astuti Prodjohardjono,
  • Desin Pambudi Sejahtera,
  • Muhammad Hardhantyo

摘要

Background

Craniopharyngiomas, benign tumors of the sellar region, frequently disrupt hypothalamic function, leading to endocrine and neurological sequelae, including sleep disorders.

Case presentation

This case highlights the diagnostic and therapeutic challenges of secondary narcolepsy in a 19-year-old woman with craniopharyngioma. The patient presented with excessive daytime sleepiness, prolonged sleep duration, no cataplexy, and cognitive dysfunction following tumor treatment. However, CSF level of orexin/hypocretin was not measured. Diagnosis of secondary narcolepsy was confirmed through overnight polysomnography and multiple sleep latency tests. Combining methylphenidate for wakefulness and donepezil for cognitive support led to symptomatic improvement.

Conclusions

This case underscores the necessity of recognizing secondary narcolepsy in patients with hypothalamic dysfunction and tailoring multidisciplinary management strategies to optimize outcomes.