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Introduction <p>Celiac disease (CD) is a chronic autoimmune disorder triggered by gluten sensitivity. Beyond its gastrointestinal presentation, CD is increasingly associated with neurological manifestations, including epilepsy.</p> Case presentation <p>To report the case of a 21-year-old female with a 15-year history of medically resistant epilepsy. Despite multiple antiseizure medications, seizure control remained inadequate. Further evaluation led to a diagnosis of biopsy-confirmed CD. The patient was initiated on a strict gluten-free diet, which resulted in significant clinical improvement and better seizure control. The ethnicity of the patient is Arab-berber (Maghrebi).</p> Conclusion <p>This case highlights the importance of considering CD in the differential diagnosis of medically resistant epilepsy. Early recognition and dietary management may improve neurological outcomes.</p>

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Favorable seizure control with a gluten-free diet in a patient with drug-resistant epilepsy and celiac disease: a case report

  • 期刊论文

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  • 发表日期：

    2026年2月5日

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  • Hajer Hassine,
  • Fatma Fatnassi,
  • Chaima Jemai,
  • Nesrine Krifa,
  • Habiba Dabbebi,
  • Souhir Monastiri,
  • Haythem Yacoub,
  • Dhouha Cherif,
  • Nadia Maamouri,
  • Hela Kchir

摘要

Introduction

Celiac disease (CD) is a chronic autoimmune disorder triggered by gluten sensitivity. Beyond its gastrointestinal presentation, CD is increasingly associated with neurological manifestations, including epilepsy.

Case presentation

To report the case of a 21-year-old female with a 15-year history of medically resistant epilepsy. Despite multiple antiseizure medications, seizure control remained inadequate. Further evaluation led to a diagnosis of biopsy-confirmed CD. The patient was initiated on a strict gluten-free diet, which resulted in significant clinical improvement and better seizure control. The ethnicity of the patient is Arab-berber (Maghrebi).

Conclusion

This case highlights the importance of considering CD in the differential diagnosis of medically resistant epilepsy. Early recognition and dietary management may improve neurological outcomes.