Scholarlink

Background <p>In multiple sclerosis (MS), axonal damage plays a significant role in contributing to disability. This study assesses the diagnostic accuracy and use of transorbital sonography (TOS) as a surrogate for axonal loss by measuring the optic nerve diameter (OND) and optic nerve sheath diameter (ONSD).</p> Methodology <p>It was a cross-sectional study in the Neurology Department, Government Medical College, Thiruvananthapuram. MS patients were enrolled, and expanded disability status scale (EDSS) scores assessed their disability. Disability was defined as EDSS &gt; 2. OND and ONSD were measured using TOS. The retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) were measured using optical coherence tomography (OCT). We constructed receiver operating characteristics curve using RNFL as gold standard to detect axonal loss and disability. The sensitivity and specificity of GCC, OND and ONSD were independently calculated from the ROC curve which could predict the disability.</p> Result <p>The EDSS scores varied from 0 to 5.5. The disabled group had 10.3 ± 1.9&#xa0;μm thinner RNFL (<i>p</i> &lt; 0.001), 40.8 ± 15.5&#xa0;μm thinner GCC (p 0.0038) as compared to the nondisabled group. OND was 3.8 ± 0.6&#xa0;mm thinner (p 0.037) and ONSD was 4.6 ± 0.6&#xa0;mm thinner (p 0.010) as compared to the control group. OND and RNFL were independent predictors for disability; the optimum cut-off to detect disability was 4.35mmfor OND and 12&#xa0;μm for RNFL; the optimum cut-off to detect axonal loss was 4.43&#xa0;mm for OND.</p> Conclusion <p>We found an optimum OND and RNFL cutoff to predict disability and an optimum cut-off for OND to predict axonal loss. TOS could be an economical and accurate alternative to OCT.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Utility of transorbital ultrasound to assess disability and axonal loss in multiple sclerosis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月25日

查看全文
  • Poornima Nair,
  • B Srikumar,
  • M. S. Sunil,
  • Thomas Iype

摘要

Background

In multiple sclerosis (MS), axonal damage plays a significant role in contributing to disability. This study assesses the diagnostic accuracy and use of transorbital sonography (TOS) as a surrogate for axonal loss by measuring the optic nerve diameter (OND) and optic nerve sheath diameter (ONSD).

Methodology

It was a cross-sectional study in the Neurology Department, Government Medical College, Thiruvananthapuram. MS patients were enrolled, and expanded disability status scale (EDSS) scores assessed their disability. Disability was defined as EDSS > 2. OND and ONSD were measured using TOS. The retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) were measured using optical coherence tomography (OCT). We constructed receiver operating characteristics curve using RNFL as gold standard to detect axonal loss and disability. The sensitivity and specificity of GCC, OND and ONSD were independently calculated from the ROC curve which could predict the disability.

Result

The EDSS scores varied from 0 to 5.5. The disabled group had 10.3 ± 1.9 μm thinner RNFL (p < 0.001), 40.8 ± 15.5 μm thinner GCC (p 0.0038) as compared to the nondisabled group. OND was 3.8 ± 0.6 mm thinner (p 0.037) and ONSD was 4.6 ± 0.6 mm thinner (p 0.010) as compared to the control group. OND and RNFL were independent predictors for disability; the optimum cut-off to detect disability was 4.35mmfor OND and 12 μm for RNFL; the optimum cut-off to detect axonal loss was 4.43 mm for OND.

Conclusion

We found an optimum OND and RNFL cutoff to predict disability and an optimum cut-off for OND to predict axonal loss. TOS could be an economical and accurate alternative to OCT.