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Background <p>Leucine-rich glioma inactivated 1 (LGI1) antibodies are associated with a limbic encephalitis syndrome characterized by faciobrachial dystonic seizures (FBDSs) that is responsive to immunotherapy. The precise pathophysiology, neural origins, and underlying mechanisms of FBDS remain incompletely understood.</p> Case report <p>We present a 54-year-old Chinese female patient with LGI1-related isolated FBDS triggered by swallowing.</p> Discussion <p>FBDS in LGI1-antibody encephalitis exhibit overlapping features with both paroxysmal kinesigenic dyskinesia (PKD) and epileptic motor seizures, both in their clinical manifestations and underlying neural mechanisms. This unique intersection suggests that FBDS represents a pathophysiological borderland between epileptic motor seizures and paroxysmal movement disorders, bridging the gap between these two diagnostic categories.</p> Conclusion <p>FBDS triggered by swallowing expands the clinical spectrum of FBDS and provides new insights into its potential reflex mechanisms, offering a valuable insight for future research into its pathophysiology.</p>

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Faciobrachial dystonic seizure can be triggered by swallowing in LGI1 encephalitis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月17日

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  • Wendeng Xu,
  • Wei Zhang,
  • Xiaofeng Zhang

摘要

Background

Leucine-rich glioma inactivated 1 (LGI1) antibodies are associated with a limbic encephalitis syndrome characterized by faciobrachial dystonic seizures (FBDSs) that is responsive to immunotherapy. The precise pathophysiology, neural origins, and underlying mechanisms of FBDS remain incompletely understood.

Case report

We present a 54-year-old Chinese female patient with LGI1-related isolated FBDS triggered by swallowing.

Discussion

FBDS in LGI1-antibody encephalitis exhibit overlapping features with both paroxysmal kinesigenic dyskinesia (PKD) and epileptic motor seizures, both in their clinical manifestations and underlying neural mechanisms. This unique intersection suggests that FBDS represents a pathophysiological borderland between epileptic motor seizures and paroxysmal movement disorders, bridging the gap between these two diagnostic categories.

Conclusion

FBDS triggered by swallowing expands the clinical spectrum of FBDS and provides new insights into its potential reflex mechanisms, offering a valuable insight for future research into its pathophysiology.