Objective <p>This study sought to assess the effectiveness of Touching-Communication-Relief therapy in providing nursing care for individuals with Parkinson’s disease (PD) with a focus on spiritual care.</p> Methods <p>Patients admitted between February and August 2022 were assigned to the observation group, while patients admitted from September 2022 to February 2023 comprised the control group; each consisted of 45 patients. The control group received standard nursing care, whereas the observation group underwent “touch, communication, and relief” therapy based on spiritual care principles. Quality of life parameters, including sleep quality, anxiety, depression, and nursing satisfaction, were assessed before and after the intervention to compare outcomes between the two groups.</p> Results <p>Forty-five patients from the control and observation groups completed the study. Significant differences were noted between the treatment groups (<i>p</i> &lt; 0.05) in the Hamilton Depression Scale, Parkinson’s Disease Sleep Scale, and Newcastle Nursing Satisfaction Scale. Nevertheless, no significant variance was identified in the post-nursing scores of the 39-item Parkinson’s Quality of Life Questionnaire (<i>p</i> &gt; 0.05) between the two groups.</p> Conclusion <p>The spiritual care perspective through multidisciplinary teamwork highlights the efficacy of Touching-Communication-Relief therapy in bolstering mood and sleep in individuals with PD, which ultimately enhanced the quality of life. This intervention is a valuable and essential complement to conventional medical, surgical, and primary care practices.</p>