Scholarlink

Background <p>This review aims to comprehensively examine the role of bilirubin in predicting severity and adverse clinical outcomes in patients with acute ischemic stroke (AIS).</p> Methods <p>We searched the electronic PubMed, Embase, Scopus, and Web of Science repositories for articles published in English available before the 15th of June 2024. The outcomes assessed were stroke severity, haemorrhagic transformation, symptomatic intracranial haemorrhage (sICH), mortality, and poor functional results.</p> Results <p>We analysed data from 13 studies. Our meta-analysis showed that both total bilirubin (RR, 1.10; 95% CI, 1.01–1.19) and direct bilirubin (RR, 1.79; 95% CI, 1.33–2.42) were independently associated with the severity of AIS. Higher quartiles of total bilirubin were associated with an increased risk of haemorrhagic transformation, but without statistical significance (RR, 2.34; 95% CI, 0.90–6.07). In addition, each unit increase in direct (RR, 1.25; 95% CI, 1.09–1.43) and indirect (RR, 1.09; 95% CI, 1.02–1.17) bilirubin levels was significantly associated with a higher risk of haemorrhagic transformation. Moreover, each unit increases in total (RR, 1.08; 95% CI, 1.04–1.12), direct (RR, 1.28; 95% CI, 1.13–1.44), and indirect (RR, 1.10; 95% CI, 1.03–1.18) bilirubin levels was significantly associated with a higher risk of sICH. Data on mortality and poor functional outcomes were insufficient.</p> Conclusion <p>Serum bilirubin levels were positively associated with the severity of AIS. The evidence suggests that bilirubin may be a potential indicator for haemorrhagic transformation and sICH after AIS.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Bilirubin as a predictor of severity and adverse clinical outcomes of acute ischemic stroke: a systematic review and meta-analysis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年4月12日

查看全文
  • Ying Zhong,
  • Lei Li

摘要

Background

This review aims to comprehensively examine the role of bilirubin in predicting severity and adverse clinical outcomes in patients with acute ischemic stroke (AIS).

Methods

We searched the electronic PubMed, Embase, Scopus, and Web of Science repositories for articles published in English available before the 15th of June 2024. The outcomes assessed were stroke severity, haemorrhagic transformation, symptomatic intracranial haemorrhage (sICH), mortality, and poor functional results.

Results

We analysed data from 13 studies. Our meta-analysis showed that both total bilirubin (RR, 1.10; 95% CI, 1.01–1.19) and direct bilirubin (RR, 1.79; 95% CI, 1.33–2.42) were independently associated with the severity of AIS. Higher quartiles of total bilirubin were associated with an increased risk of haemorrhagic transformation, but without statistical significance (RR, 2.34; 95% CI, 0.90–6.07). In addition, each unit increase in direct (RR, 1.25; 95% CI, 1.09–1.43) and indirect (RR, 1.09; 95% CI, 1.02–1.17) bilirubin levels was significantly associated with a higher risk of haemorrhagic transformation. Moreover, each unit increases in total (RR, 1.08; 95% CI, 1.04–1.12), direct (RR, 1.28; 95% CI, 1.13–1.44), and indirect (RR, 1.10; 95% CI, 1.03–1.18) bilirubin levels was significantly associated with a higher risk of sICH. Data on mortality and poor functional outcomes were insufficient.

Conclusion

Serum bilirubin levels were positively associated with the severity of AIS. The evidence suggests that bilirubin may be a potential indicator for haemorrhagic transformation and sICH after AIS.