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Rationale &amp; objective <p>A high prevalence of vitamin D deficiency and insufficiency has been documented among individuals who have undergone kidney transplantation. The efficacy of post-transplantation vitamin D therapy remains inconclusive when examined through isolated studies. Therefore, a meta-analytic approach was employed to consolidate current literature and assess the influence of vitamin D supplementation on recipient outcomes following renal transplantation.</p> Selection criteria for studies <p>Included were randomized controlled trials and prospective cohort studies related to kidney transplantation, as well as research examining the impact of regular vitamin D supplementation on outcomes following kidney transplantation.</p> Results <p>8 studies ultimately satisfied selection criteria for this review. The temporal scope of included studies stretched from 2005 to 2025, encompassing patient populations between 79 and 536 recipients per investigation. Post-baseline surveillance periods diverged substantially, measuring 12 through 24 months. Vitamin D was administered at daily doses between 800 IU and 7000 IU. Supplementation produced significant elevation in 25(OH)D concentrations. A downward trend in parathyroid hormone levels was observed following vitamin D supplementation, though this reduction did not reach statistical significance. Notably, this was achieved safely without provoking hypercalcemia. Post-operative femoral neck bone mineral density T-score additionally showed improvement with vitamin D intervention.</p> Conclusion <p>Post-transplant nutritional vitamin D supplementation increased serum 25(OH)D levels and improved femoral neck bone mineral density t-score in kidney transplant recipients. A downward trend in parathyroid hormone was observed but did not reach statistical significance. Whether vitamin D supplementation improves post-transplant bone disease remains uncertain and requires further investigation.</p> Registration <p>Registered at PROSPERO with identification number CRD420251009160.</p>

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Impact of vitamin D supplementation on the outcomes of kidney transplant recipients: a systematic review and meta-analysis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年7月10日

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  • Bin-Qi Yang,
  • Yang-Juan Bai,
  • Ya-Mei Li,
  • Zeng-Jie Wang,
  • Yuan-Zhen He,
  • Yun-Ying Shi

摘要

Rationale & objective

A high prevalence of vitamin D deficiency and insufficiency has been documented among individuals who have undergone kidney transplantation. The efficacy of post-transplantation vitamin D therapy remains inconclusive when examined through isolated studies. Therefore, a meta-analytic approach was employed to consolidate current literature and assess the influence of vitamin D supplementation on recipient outcomes following renal transplantation.

Selection criteria for studies

Included were randomized controlled trials and prospective cohort studies related to kidney transplantation, as well as research examining the impact of regular vitamin D supplementation on outcomes following kidney transplantation.

Results

8 studies ultimately satisfied selection criteria for this review. The temporal scope of included studies stretched from 2005 to 2025, encompassing patient populations between 79 and 536 recipients per investigation. Post-baseline surveillance periods diverged substantially, measuring 12 through 24 months. Vitamin D was administered at daily doses between 800 IU and 7000 IU. Supplementation produced significant elevation in 25(OH)D concentrations. A downward trend in parathyroid hormone levels was observed following vitamin D supplementation, though this reduction did not reach statistical significance. Notably, this was achieved safely without provoking hypercalcemia. Post-operative femoral neck bone mineral density T-score additionally showed improvement with vitamin D intervention.

Conclusion

Post-transplant nutritional vitamin D supplementation increased serum 25(OH)D levels and improved femoral neck bone mineral density t-score in kidney transplant recipients. A downward trend in parathyroid hormone was observed but did not reach statistical significance. Whether vitamin D supplementation improves post-transplant bone disease remains uncertain and requires further investigation.

Registration

Registered at PROSPERO with identification number CRD420251009160.