Scholarlink

<p>The kidney maintains the structural and functional integrity of the human body through its sophisticated internal architecture. Specialized cell types are organized into distinct compartments, each serving specific functions. Recent advancements in sequencing technologies, such as single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST), have significantly enhanced our understanding of the cellular-level pathophysiological mechanisms underlying disease onset and progression, leading to the discovery of numerous biomarkers. This review summarizes the latest applications and advancements in scRNA-seq and its integration with ST in the discovery of potential biomarkers for kidney diseases, offering new perspectives and directions for future research and clinical applications.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Single-cell RNA sequencing and spatial transcriptomics in the discovery of kidney disease potential biomarkers: a narrative review

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月1日

查看全文
  • Yue Guo,
  • Dan Yi,
  • Yonghe Zhang,
  • Junjun Luan,
  • Hua Zhou

摘要

The kidney maintains the structural and functional integrity of the human body through its sophisticated internal architecture. Specialized cell types are organized into distinct compartments, each serving specific functions. Recent advancements in sequencing technologies, such as single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST), have significantly enhanced our understanding of the cellular-level pathophysiological mechanisms underlying disease onset and progression, leading to the discovery of numerous biomarkers. This review summarizes the latest applications and advancements in scRNA-seq and its integration with ST in the discovery of potential biomarkers for kidney diseases, offering new perspectives and directions for future research and clinical applications.