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Purpose <p>Atrial cardiomyopathy (ATC) is characterized by structural and functional atrial remodeling and is associated with adverse cardiovascular outcomes. Native T1 mapping has emerged as a sensitive technique for tissue characterization; however, data on left atrial (LA) native T1 mapping remain limited. We evaluated the feasibility and reproducibility of LA T1 measurements using non-contrast 3.0-T cardiac magnetic resonance (CMR), thereby providing a methodological foundation for future studies of atrial tissue characterization.</p> Methods <p>Healthy volunteers in sinus rhythm underwent non-contrast 3.0-T CMR, including native T1 mapping using a modified Look-Locker inversion recovery (5s(3s)3s MOLLI) sequence. LA native T1 values were measured in the 2-, 3-, and 4-chamber long-axis views. Two independent specialists measured LA native T1 values using regions of interest placed within the inner 2 reconstructed pixels of the LA wall to minimize in-plane partial volume effects. Feasibility was assessed by the proportion of measurable studies, and reproducibility by intra- and inter-observer intraclass correlation coefficients (ICC). Additional analyses were performed to assess potential blood-pool contamination.</p> Results <p>Forty volunteers (50% female; mean age 33.6 ± 6.1 years; body mass index of 22.7 ± 3.2&#xa0;kg/m²) were included. LA native T1 values were measurable in 62.5%, 95.0%, and 75.0% of subjects in the 2-, 3-, and 4-chamber views, respectively, identifying the 3-chamber view as the most feasible imaging plane. Mean LA native T1 values were consistent across views (1,441–1,448 ms; all <i>p</i> &gt; 0.05) without gender difference. Reproducibility was excellent, with intra-observer ICCs of 0.921–0.940 and inter-observer ICCs of 0.894–0.920. Agreement between views was good (ICC 0.709–0.878) without significant proportional bias. Blood-pool T1 values were substantially higher than LA T1 values (1,859–1,868 ms vs. 1,441–1,448 ms) and showed no significant correlation. Validation analyses demonstrated a progressive increase in blood-pool T1 values with increasing distance from the LA wall, supporting measurement specificity.</p> Conclusion <p>Non-contrast T1 mapping enables feasible and highly reproducible quantification of LA native T1 values. The 3-chamber view demonstrated the highest measurability and may be the preferred imaging plane for LA tissue characterization. These findings provide a methodological framework for future investigations of ATC and other atrial diseases.</p> Clinical trial number <p>Not applicable.</p> Graphical Abstract <p></p>

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Assessment of left atrial native T1 values using non-contrast 3.0 T cardiac magnetic resonance imaging: a feasibility and reproducibility study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年8月1日

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  • Nonthikorn Theerasuwipakorn,
  • Nabhat Noparatkailas,
  • Piyanun Sanguanwong,
  • Sittinop Titichoatrattana,
  • Rattanaporn Prasertdumrongchai,
  • Yongkasem Vorasettakarnkij,
  • Monravee Tumkosit,
  • David C. Wendell,
  • Pairoj Chattranukulchai

摘要

Purpose

Atrial cardiomyopathy (ATC) is characterized by structural and functional atrial remodeling and is associated with adverse cardiovascular outcomes. Native T1 mapping has emerged as a sensitive technique for tissue characterization; however, data on left atrial (LA) native T1 mapping remain limited. We evaluated the feasibility and reproducibility of LA T1 measurements using non-contrast 3.0-T cardiac magnetic resonance (CMR), thereby providing a methodological foundation for future studies of atrial tissue characterization.

Methods

Healthy volunteers in sinus rhythm underwent non-contrast 3.0-T CMR, including native T1 mapping using a modified Look-Locker inversion recovery (5s(3s)3s MOLLI) sequence. LA native T1 values were measured in the 2-, 3-, and 4-chamber long-axis views. Two independent specialists measured LA native T1 values using regions of interest placed within the inner 2 reconstructed pixels of the LA wall to minimize in-plane partial volume effects. Feasibility was assessed by the proportion of measurable studies, and reproducibility by intra- and inter-observer intraclass correlation coefficients (ICC). Additional analyses were performed to assess potential blood-pool contamination.

Results

Forty volunteers (50% female; mean age 33.6 ± 6.1 years; body mass index of 22.7 ± 3.2 kg/m²) were included. LA native T1 values were measurable in 62.5%, 95.0%, and 75.0% of subjects in the 2-, 3-, and 4-chamber views, respectively, identifying the 3-chamber view as the most feasible imaging plane. Mean LA native T1 values were consistent across views (1,441–1,448 ms; all p > 0.05) without gender difference. Reproducibility was excellent, with intra-observer ICCs of 0.921–0.940 and inter-observer ICCs of 0.894–0.920. Agreement between views was good (ICC 0.709–0.878) without significant proportional bias. Blood-pool T1 values were substantially higher than LA T1 values (1,859–1,868 ms vs. 1,441–1,448 ms) and showed no significant correlation. Validation analyses demonstrated a progressive increase in blood-pool T1 values with increasing distance from the LA wall, supporting measurement specificity.

Conclusion

Non-contrast T1 mapping enables feasible and highly reproducible quantification of LA native T1 values. The 3-chamber view demonstrated the highest measurability and may be the preferred imaging plane for LA tissue characterization. These findings provide a methodological framework for future investigations of ATC and other atrial diseases.

Clinical trial number

Not applicable.

Graphical Abstract