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Objective <p>This study aims to explore the correlation between <sup>11</sup>C-CFT PET/CT imaging parameters and clinical characteristics of PD patients.</p> Methods <p>This study retrospectively included 69 PD patients and 10 healthy controls who had undergone <sup>11</sup>C-CFT imaging to analyze the correlation between <sup>11</sup>C-CFT imaging parameters and clinical features. The PD patients were divided into TD and PIGD groups based on the TD/PIGD score ratio, and H-Y stage 1–2 and H-Y stage 2.5-3 groups according to the H-Y stage. The differences in <sup>11</sup>C-CFT parameters were compared between the groups.</p> Results <p>After FDR correction for 160 statistical tests, a strong negative correlation was identified between age and both the volume (<i>r</i> = -0.471, q &lt; 0.01) and surface area (<i>r</i> = -0.474, q &lt; 0.01) of the caudate nucleus. While several correlations between imaging parameters and clinical scores (e.g., UPDRS, bradykinesia) were observed at the nominal significance level (uncorrected <i>P</i> &lt; 0.05), none of these associations remained statistically significant after FDR correction.</p> Conclusions <p>The most robust finding of this study is a significant age-related decline in caudate nucleus morphology in early to mid-stage PD. After rigorous statistical correction for multiple comparisons, no other significant correlations were found between dopaminergic PET/CT parameters and clinical scores.</p>

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Correlation analysis of 11C-CFT PET/CT parameters with clinical characteristics of patients with early to mid-stage Parkinson’s disease

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月28日

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  • Tao Zhu,
  • Rui Zuo,
  • Zhu Xia,
  • Wenbo Li,
  • Lili Guan,
  • Jing Chen,
  • Lu Xu,
  • Hua Pang

摘要

Objective

This study aims to explore the correlation between 11C-CFT PET/CT imaging parameters and clinical characteristics of PD patients.

Methods

This study retrospectively included 69 PD patients and 10 healthy controls who had undergone 11C-CFT imaging to analyze the correlation between 11C-CFT imaging parameters and clinical features. The PD patients were divided into TD and PIGD groups based on the TD/PIGD score ratio, and H-Y stage 1–2 and H-Y stage 2.5-3 groups according to the H-Y stage. The differences in 11C-CFT parameters were compared between the groups.

Results

After FDR correction for 160 statistical tests, a strong negative correlation was identified between age and both the volume (r = -0.471, q < 0.01) and surface area (r = -0.474, q < 0.01) of the caudate nucleus. While several correlations between imaging parameters and clinical scores (e.g., UPDRS, bradykinesia) were observed at the nominal significance level (uncorrected P < 0.05), none of these associations remained statistically significant after FDR correction.

Conclusions

The most robust finding of this study is a significant age-related decline in caudate nucleus morphology in early to mid-stage PD. After rigorous statistical correction for multiple comparisons, no other significant correlations were found between dopaminergic PET/CT parameters and clinical scores.