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Background <p>Chronic hepatitis B poses a major global health challenge, especially in developing countries. It significantly contributes to morbidity and mortality from liver cirrhosis and hepatocellular carcinoma.</p> Objective <p>To evaluate diagnostic performance of ultrasound shear wave elastography (USWE), S index, Z index, Fibrometer in continuous differentiation of liver fibrosis in a retrospective chronic hepatitis B patients’ cohort.</p> Materials and methods <p>We collected liver stiffness values measured by USWE and laboratory indicators from 146 patients with chronic hepatitis B at Baoji Central Hospital. Serum fibrosis models were calculated using formulas, including S index, Z index, and Fibrometer. Using liver biopsy pathology as a reference, the diagnostic efficacy of each indicator for liver fibrosis staging was evaluated using receiver operating characteristic curves (ROC).</p> Results <p>S index and USWE demonstrated comparable diagnostic accuracy for liver fibrosis staging with areas under ROC (AUCs) of 0.791 vs. 0.860 (<i>p</i> = 0.679) for significant fibrosis (S ≥ 2), 0.867 vs. 0.942 (<i>p</i> = 0.074) for severe fibrosis (S ≥ 3), and 0.961 vs. 0.932 (<i>p</i> = 0.508) for cirrhosis (S4). The two indices exhibited superior performance over Fibrometer across all stages (S index/USWE vs. Fibrometer-AUCs: 0.791/0.806 vs. 0.575, &lt; 0.001 for S ≥ 2; 0.867/0.940 vs. 0.625, <i>p</i> &lt; 0.001 for S ≥ 3; 0.961/0.932 vs. 0.781, <i>p</i> = 0.004/0.025 for S4). Compared with Z index, they showed better diagnostic capacity for S ≥ 2 (AUCs 0.791/0.806 vs. 0.575, <i>p</i> &lt; 0.001) and S ≥ 3 (0.867/0.942 vs. 0.673, <i>p</i> &lt; 0.001), while maintaining equivalent accuracy for cirrhosis detection (AUCs 0.961/0.932 vs. 0.914, <i>p</i> = 0.209/0.747).</p> Conclusion <p>The S index is equally effective as the USWE in diagnosing liver fibrosis among patients with chronic hepatitis B, and it is superior to both the Z index and Fibrometer.</p>

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S index: a predictor comparable to ultrasound shear wave elastography in assessing liver fibrosis in patients with chronic hepatitis B

  • 期刊论文

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  • 发表日期：

    2025年7月28日

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  • Sujuan Guo,
  • Lu Gan,
  • Feng Du,
  • Qiang Feng,
  • Jiahua Li,
  • Qinyun Wan,
  • Qiannan Meng,
  • Yaoren Zhang,
  • Yonghao Ji,
  • Jianxue Liu

摘要

Background

Chronic hepatitis B poses a major global health challenge, especially in developing countries. It significantly contributes to morbidity and mortality from liver cirrhosis and hepatocellular carcinoma.

Objective

To evaluate diagnostic performance of ultrasound shear wave elastography (USWE), S index, Z index, Fibrometer in continuous differentiation of liver fibrosis in a retrospective chronic hepatitis B patients’ cohort.

Materials and methods

We collected liver stiffness values measured by USWE and laboratory indicators from 146 patients with chronic hepatitis B at Baoji Central Hospital. Serum fibrosis models were calculated using formulas, including S index, Z index, and Fibrometer. Using liver biopsy pathology as a reference, the diagnostic efficacy of each indicator for liver fibrosis staging was evaluated using receiver operating characteristic curves (ROC).

Results

S index and USWE demonstrated comparable diagnostic accuracy for liver fibrosis staging with areas under ROC (AUCs) of 0.791 vs. 0.860 (p = 0.679) for significant fibrosis (S ≥ 2), 0.867 vs. 0.942 (p = 0.074) for severe fibrosis (S ≥ 3), and 0.961 vs. 0.932 (p = 0.508) for cirrhosis (S4). The two indices exhibited superior performance over Fibrometer across all stages (S index/USWE vs. Fibrometer-AUCs: 0.791/0.806 vs. 0.575, < 0.001 for S ≥ 2; 0.867/0.940 vs. 0.625, p < 0.001 for S ≥ 3; 0.961/0.932 vs. 0.781, p = 0.004/0.025 for S4). Compared with Z index, they showed better diagnostic capacity for S ≥ 2 (AUCs 0.791/0.806 vs. 0.575, p < 0.001) and S ≥ 3 (0.867/0.942 vs. 0.673, p < 0.001), while maintaining equivalent accuracy for cirrhosis detection (AUCs 0.961/0.932 vs. 0.914, p = 0.209/0.747).

Conclusion

The S index is equally effective as the USWE in diagnosing liver fibrosis among patients with chronic hepatitis B, and it is superior to both the Z index and Fibrometer.