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Background <p>To assess the effect of the combination of deep learning reconstruction (DLR) and time-resolved maximum intensity projection (tMIP) or time-resolved average (tAve) post-processing method on image quality of CTA derived from low-dose cerebral CTP.</p> Methods <p>Thirty patients underwent regular dose CTP (Group A) and other thirty with low-dose (Group B) were retrospectively enrolled. Group A were reconstructed with hybrid iterative reconstruction (R-HIR). In Group B, four image datasets of CTA were gained: L-HIR, L-DLR, L-DLR<sub>tMIP</sub> and L-DLR<sub>tAve</sub>. The CT attenuation, image noise, signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR) and subjective images quality were calculated and compared. The Intraclass Correlation (ICC) between CTA and MRA of two subgroups were calculated.</p> Results <p>The low-dose group achieved reduction of radiation dose by 33% in single peak arterial phase and 18% in total compared to the regular dose group (single phase: 0.12 mSv vs 0.18 mSv; total: 1.91mSv vs 2.33mSv). The L-DLR<sub>tMIP</sub> demonstrated higher CT values in vessels compared to R-HIR (all <i>P</i> &lt; 0.05). The CNR of vessels in L-HIR were statistically inferior to R-HIR (all <i>P</i> &lt; 0.001). There was no significant different in image noise and CNR of vessels between L-DLR and R-HIR (all <i>P</i> &gt; 0.05, except <i>P</i> = 0.05 for CNR of ICAs, 77.19 ± 21.64 vs 73.54 ± 37.03). However, the L-DLR<sub>tMIP</sub> and L-DLR<sub>tAve</sub> presented lower image noise, higher CNR (all <i>P</i> &lt; 0.05) and subjective scores (all <i>P</i> &lt; 0.001) in vessels than R-HIR. The diagnostic accuracy in Group B was excellent (ICC = 0.944).</p> Conclusion <p>Combining DLR with tMIP or tAve allows for reduction in radiation dose by about 33% in single peak arterial phase and 18% in total in CTP scanning, while further improving image quality of CTA derived from CTP data when compared to HIR.</p>

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Application of deep learning reconstruction combined with time-resolved post-processing method to improve image quality in CTA derived from low-dose cerebral CT perfusion data

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  • 发表日期：

    2025年4月29日

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  • Jiajing Tong,
  • Tong Su,
  • Yu Chen,
  • Xiaobo Zhang,
  • Ming Yao,
  • Yanling Wang,
  • Haozhe Liu,
  • Min Xu,
  • Jian Wang,
  • Zhengyu Jin

摘要

Background

To assess the effect of the combination of deep learning reconstruction (DLR) and time-resolved maximum intensity projection (tMIP) or time-resolved average (tAve) post-processing method on image quality of CTA derived from low-dose cerebral CTP.

Methods

Thirty patients underwent regular dose CTP (Group A) and other thirty with low-dose (Group B) were retrospectively enrolled. Group A were reconstructed with hybrid iterative reconstruction (R-HIR). In Group B, four image datasets of CTA were gained: L-HIR, L-DLR, L-DLRtMIP and L-DLRtAve. The CT attenuation, image noise, signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR) and subjective images quality were calculated and compared. The Intraclass Correlation (ICC) between CTA and MRA of two subgroups were calculated.

Results

The low-dose group achieved reduction of radiation dose by 33% in single peak arterial phase and 18% in total compared to the regular dose group (single phase: 0.12 mSv vs 0.18 mSv; total: 1.91mSv vs 2.33mSv). The L-DLRtMIP demonstrated higher CT values in vessels compared to R-HIR (all P < 0.05). The CNR of vessels in L-HIR were statistically inferior to R-HIR (all P < 0.001). There was no significant different in image noise and CNR of vessels between L-DLR and R-HIR (all P > 0.05, except P = 0.05 for CNR of ICAs, 77.19 ± 21.64 vs 73.54 ± 37.03). However, the L-DLRtMIP and L-DLRtAve presented lower image noise, higher CNR (all P < 0.05) and subjective scores (all P < 0.001) in vessels than R-HIR. The diagnostic accuracy in Group B was excellent (ICC = 0.944).

Conclusion

Combining DLR with tMIP or tAve allows for reduction in radiation dose by about 33% in single peak arterial phase and 18% in total in CTP scanning, while further improving image quality of CTA derived from CTP data when compared to HIR.